S39AE_HUMAN Q15043
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UniProt:Q15043
Recommended name：Metal cation symporter ZIP14
EC number：
Alternative names：(LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
Cleaved into：
GeneID：23516
Gene names (primary )：SLC39A14
Gene names (synonym )：KIAA0062 ZIP14
Gene names (ORF )：
Length：492
Mass：54212
Sequence：MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQQLKALLNHLDVGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPTILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFFFTEKILKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPMVDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAGSHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMVVLTMYSGQIQIG
Tissue specificity：Ubiquitously expressed, with higher expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart (PubMed:7584044, PubMed:15642354, PubMed:20682781). Weakly expressed in spleen, thymus, and peripheral blood leukocytes (PubMed:7584044). Expressed in liver and in brain by large neurons in the globus pallidus, the insular cortex and the dentate nucleus and to a lower extent in the putamen and the caudate nucleus (at protein level) (PubMed:27231142). Expressed in osteoblasts and giant osteoclast-like cells, but not in osteocytes found osteoblastoma and giant cell tumors (at protein level) (PubMed:29621230). Expressed by microvascular capillary endothelial cells that constitute the blood-brain barrier (at protein level) (PubMed:31699897). Expressed by macrophages (PubMed:23052185). {ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:20682781, ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:31699897, ECO:0000269|PubMed:7584044}.; [Isoform 2]: Widely expressed but not detected in brain, heart, skeletal muscle, placenta and fetal skin. {ECO:0000269|PubMed:27231142}.
Induction：Up-regulated by iron (at protein level) (PubMed:24927598). Down-regulation upon iron depletion occurs through proteasomal degradation of the intracellular pool (PubMed:24927598). Up-regulated by tunicamycin, a drug inducing endoplasmic reticulum stress (at protein level) (PubMed:28673968). Up-regulated by lipopolysaccharide/LPS (PubMed:23052185). {ECO:0000269|PubMed:23052185, ECO:0000269|PubMed:24927598, ECO:0000269|PubMed:28673968}.
Developmental stage：
Protein families：ZIP transporter (TC 2.A.5) family