DCSTP_MOUSE Q7TNJ0
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UniProt:Q7TNJ0
Recommended name：Dendritic cell-specific transmembrane protein
EC number：
Alternative names：(DC-STAMP) (mDC-STAMP) (Dendrocyte-expressed seven transmembrane protein) (Transmembrane 7 superfamily member 4)
Cleaved into：
GeneID：75766
Gene names (primary )：Dcstamp
Gene names (synonym )：Tm7sf4
Gene names (ORF )：
Length：470
Mass：53876
Sequence：MRLWTLGTSIFLRLWGTYVFPRSPSWLDFIQHLGVCCFVAFLSVSLFSAAFYWILPPVALLSSVWMITCVFLCCSKRARCFILLAVLSCGLREGRNALIAAGTGVVIFGHVENIFYNFRGLLDSMTCNLRAKSFSVHFPLLKRYTEAIQWIYGLATPLNLFDDLVSWNQTLVVSLFSPSHALEAHMNDTRGEVLGVLHHMVVTTELLTSVGQKLLALAGLLLILVSTGLFLKRFLGPCGWKYENVYITKQFVRFDEKERHQQRPCVLPLNKKERKKYVIVPSLQLTPKEKKTLGLFFLPVLTYLYMWVLFAAVDYLLYRLISSMNKQFQSLPGLEVHLKLRGEKQGTQGVVHDSAFNISMFEPSCIPKPRLSVSETWVPLSIILLTLIILGLLSSMLMQLKILVSVSFYPKVERERIEYLHAKLLEKRSKQPLREADGKPSLYFKKIHFWFPVLKMIRKKQTIPANEDDL
Tissue specificity：Expressed in macrophages and bone marrow dendritic cells (BM-DC). Weakly expressed in the spleen and lymph node. Highly expressed in multi-nuclear osteoclasts compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs). Isoform 1 and isoform 2 are expressed in osteoclasts. {ECO:0000269|PubMed:15601667, ECO:0000269|PubMed:16061724, ECO:0000269|PubMed:22337159}.
Induction：Up-regulated by IL4/interleukin-4, macrophage colony-stimulating factor (M-CSF), receptor activator of NF-KB ligand (RANKL), lipopolysaccharide (LPS) and toll-like receptor (TLR). Up-regulated by TNFSF11-induced osteoclast differentiation in combination with TNF-alpha. Down-regulated upon dendritic cell (DC) maturation. {ECO:0000269|PubMed:15452179, ECO:0000269|PubMed:15601667, ECO:0000269|PubMed:16061724, ECO:0000269|PubMed:18952287, ECO:0000269|PubMed:22337159}.
Developmental stage：
Protein families：