S4A10_MOUSE Q5DTL9
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UniProt:Q5DTL9
Recommended name：Sodium-driven chloride bicarbonate exchanger
EC number：
Alternative names：(Solute carrier family 4 member 10)
Cleaved into：
GeneID：94229
Gene names (primary )：Slc4a10
Gene names (synonym )：Kiaa4136 Ncbe
Gene names (ORF )：
Length：1118
Mass：125817
Sequence：MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHLPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTIEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLANRIPIVRSFADIGKKQSEPNSMDKNAGQVVSPQSAPACAENKNDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKIPAVPNGTAAHGEAEPHGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSETYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWRESNLSASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMSKTAMWGNLLVTADNSKEKESRFPSKSSPS
Tissue specificity：In the brain, detected in cerebral cortex, subcortex, cerebellum, hippocampus and medulla (at protein level) (PubMed:20541593, PubMed:18061361, PubMed:21439947, PubMed:24905082). In the cerebrum, expressed at high levels throughout the cortex, at lower levels in striatum and not detectable in the corpus callosum (at protein level) (PubMed:20541593). In the cerebellum, detected at high levels in the molecular layer but at very low levels in the granular layer (at protein level) (PubMed:20541593). In the central nervous system, detected in neurons in the olfactory bulb, cortex and cerebellum (at protein level) (PubMed:18165320). Within the hippocampus, abundantly expressed in CA3 pyramidal cells (at protein level) (PubMed:18165320). Strongly expressed in the retina with high levels in bipolar and amacrine cells (at protein level) (PubMed:23056253). Expressed at high levels in brain and at low levels in the pituitary, testis, kidney and ileum (PubMed:10993873). Also expressed in pancreatic islets (PubMed:10993873). Expressed in the epithelial cells of the choroid plexus (PubMed:14592810, PubMed:15567717). During embryonic development, expressed in neurons of the central nervous system (PubMed:15567717). Also expressed in the peripheral nervous system and in non-neuronal tissues such as the dura and some epithelia including the acid-secreting epithelium of the stomach and the duodenal epithelium (PubMed:15567717). In the embryonic retina, expression is restricted to the neuronal cell layer and the retinal pigment epithelium (PubMed:15567717). {ECO:0000269|PubMed:10993873, ECO:0000269|PubMed:14592810, ECO:0000269|PubMed:15567717, ECO:0000269|PubMed:18061361, ECO:0000269|PubMed:18165320, ECO:0000269|PubMed:20541593, ECO:0000269|PubMed:21439947, ECO:0000269|PubMed:23056253, ECO:0000269|PubMed:24905082}.
Induction：Repressed in the brain by chronic continuous hypoxia (at protein level). {ECO:0000269|PubMed:17928512}.
Developmental stage：In the embryonic central nervous system, detected at 12.5 dpc when expression is observed in all areas of the brain including the cerebellum (PubMed:15567717). In the embryonic cerebral cortex, detected at 14.5 dpc with levels increasing at 18.5 dpc (PubMed:15567717). {ECO:0000269|PubMed:15567717}.
Protein families：Anion exchanger (TC 2.A.31) family