ARC_MOUSE Q9WV31
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UniProt:Q9WV31
Recommended name：Activity-regulated cytoskeleton-associated protein
EC number：
Alternative names：(mArc) (Activity-regulated gene 3.1 protein) (ARC/ARG3.1) (Arg3.1)
Cleaved into：
GeneID：11838
Gene names (primary )：Arc
Gene names (synonym )：
Gene names (ORF )：
Length：396
Mass：45321
Sequence：MELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRRTHRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQEADGYDYTVSPYAITPPPAAGELPEQESVEAQQYQSWGPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELELPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKLKRFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSGTPLPTEDETEALTPALTSESVASDRTQPE
Tissue specificity：Expressed in brain and testis (PubMed:12493697). In primary visual cortex, detected in all cortical layers with the exception of layer 5: present at highest level in layers 2/3 and 4, the predominant sites of ocular dominance plasticity (at protein level) (PubMed:20228806). Also expressed in skin-migratory dendritic cells (PubMed:28783680). {ECO:0000269|PubMed:12493697, ECO:0000269|PubMed:20228806, ECO:0000269|PubMed:28783680}.
Induction：Arc expression is regulated at transcription, post-transcription and translation levels (PubMed:19116276, PubMed:24094104). Expression is induced by neuronal and synaptic activity (PubMed:19116276, PubMed:24094104). {ECO:0000269|PubMed:19116276, ECO:0000269|PubMed:24094104}.
Developmental stage：Ubiquitously expressed in early mouse embryos (PubMed:10727859). Detectable in brain from postnatal week 1, in testis from postnatal week 3. {ECO:0000269|PubMed:10727859, ECO:0000269|PubMed:12493697}.
Protein families：ARC/ARG3.1 family