GATM_RAT P50442
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UniProt:P50442
Recommended name：Glycine amidinotransferase, mitochondrial
EC number：EC:2.1.4.1
Alternative names：L-arginine:glycine amidinotransferase Transamidinase
Cleaved into：
GeneID：81660
Gene names (primary )：Gatm
Gene names (synonym )：Agat
Gene names (ORF )：
Length：423
Mass：48,242
Sequence：MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATASSQNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVKRPDPIDWSLKYKTPDFESTGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYDQDYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD
Tissue specificity：Highly expressed in the kidney and pancreas, especially in the proximal tubules of the kidney, and alpha cells of the pancreatic islets (at protein level). Moderately expressed in liver hepatocytes (at protein level). Expressed in the kidney, pancreas, liver, colon, ileum, jejunum, heart and skeletal muscle. In reproductive tissues, expressed in the testis, epididymis, ovary, oviduct and uterus. Expressed throughout the brain in neurons, astrocytes and oligodendrocytes. In 12.5 dpc embryos, it is expressed in the middle part of the somites, hepatic primordium and wall of the dorsal aorta. Expressed in 15.5 dpc embryos in isolated cells throughout the central nervous system, skeletal muscles, gonad primordia, caudal somites, liver and pancreas, but not in the choroid plexus, root ganglia or kidney. Expressed in skeletal muscle, kidney, pancreas, central nervous system, liver and intestine epithelial cells, but not in epidermis, dermis, olfactory epithelium, trachea, lung, stomach or heart in 18.5 dpc embryos. 5 s
Induction：Expressed throughout embryogenesis. Expression in the colon and small intestine is highest in newborns and declines with age. Expression in the kidney increases with age. 2 Publications
Developmental stage：Expression is induced by growth hormone and repressed by dietary intake of creatine. 3 s
Protein families：