NEUR4_HUMAN Q8WWR8
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UniProt:Q8WWR8
Recommended name:Sialidase-4
EC number:EC:3.2.1.18
Alternative names:(N-acetyl-alpha-neuraminidase 4)
Cleaved into:
GeneID:129807
Gene names (primary ):NEU4
Gene names (synonym ):
Gene names (ORF ):LP5125
Length:484
Mass:51572
Sequence:MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS
Tissue specificity:[Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon. {ECO:0000269|PubMed:14962670, ECO:0000269|PubMed:15847605}.; [Isoform 2]: Highly expressed in brain and at lower levels in kidney and liver. {ECO:0000269|PubMed:15847605}.
Induction:Down-regulated during monocyte to macrophage differentiation. {ECO:0000269|PubMed:15885103}.
Developmental stage:
Protein families:Glycosyl hydrolase 33 family