CCL18_HUMAN P55774
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UniProt:P55774
Recommended name：C-C motif chemokine 18
EC number：
Alternative names：(Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18)
Cleaved into：CCL18(1-68); CCL18(3-69); CCL18(4-69)
GeneID：6362
Gene names (primary )：CCL18
Gene names (synonym )：AMAC1 DCCK1 MIP4 PARC SCYA18
Gene names (ORF )：
Length：89
Mass：9849
Sequence：MKGLAAALLVLVCTMALCSCAQVGTNKELCCLVYTSWQIPQKFIVDYSETSPQCPKPGVILLTKRGRQICADPNKKWVQKYISDLKLNA
Tissue specificity：Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. {ECO:0000269|PubMed:11745396}.
Induction：Specifically induced in macrophages by IL4/interleukin-4, IL13/interleukin-13, and IL10/interleukin-10. Expression is inhibited by IFNG/IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL4/interleukin-4. Strongly induced in several human cell lines, including monocytic U-937 cells, by phorbol myristate acetate (PMA). Induced in PBMC by staphylococcal enterotoxins SEA and SEB. {ECO:0000269|PubMed:11745396}.
Developmental stage：
Protein families：Intercrine beta (chemokine CC) family