CP7A1_HUMAN   P22680


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UniProt:P22680

Recommended name:Cytochrome P450 7A1

EC number:

Alternative names:(24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)

Cleaved into:

GeneID:1581

Gene names  (primary ):CYP7A1

Gene names  (synonym ):CYP7

Gene names  (ORF ):

Length:504

Mass:57661

Sequence:MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL

Tissue specificity:Detected in liver. {ECO:0000269|PubMed:15796896}.

Induction:Up-regulated by glucose and by cholestyramine. Down-regulated by chenodeoxycholic acid. {ECO:0000269|PubMed:15796896, ECO:0000269|PubMed:19965590}.

Developmental stage:

Protein families:Cytochrome P450 family


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