CP7A1_HUMAN P22680
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UniProt:P22680
Recommended name:Cytochrome P450 7A1
EC number:
Alternative names:(24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)
Cleaved into:
GeneID:1581
Gene names (primary ):CYP7A1
Gene names (synonym ):CYP7
Gene names (ORF ):
Length:504
Mass:57661
Sequence:MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL
Tissue specificity:Detected in liver. {ECO:0000269|PubMed:15796896}.
Induction:Up-regulated by glucose and by cholestyramine. Down-regulated by chenodeoxycholic acid. {ECO:0000269|PubMed:15796896, ECO:0000269|PubMed:19965590}.
Developmental stage:
Protein families:Cytochrome P450 family