PDK4_HUMAN Q16654
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UniProt:Q16654
Recommended name：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
EC number：EC:2.7.11.2
Alternative names：(Pyruvate dehydrogenase kinase isoform 4)
Cleaved into：
GeneID：5166
Gene names (primary )：PDK4
Gene names (synonym )：PDHK4
Gene names (ORF )：
Length：411
Mass：46469
Sequence：MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
Tissue specificity：Ubiquitous; highest levels of expression in heart and skeletal muscle. {ECO:0000269|PubMed:14966024, ECO:0000269|PubMed:21816445}.
Induction：Up-regulated by prolonged fasting, in glucose-deprived cells and in response to a high-fat diet. Down-regulated by insulin. Up-regulated by PPARD. {ECO:0000269|PubMed:14966024, ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:17669420, ECO:0000269|PubMed:20715114, ECO:0000269|PubMed:21816445}.
Developmental stage：
Protein families：PDK/BCKDK protein kinase family