BIRC5_HUMAN O15392
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UniProt:O15392
Recommended name：Baculoviral IAP repeat-containing protein 5
EC number：
Alternative names：(Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)
Cleaved into：
GeneID：332
Gene names (primary )：BIRC5
Gene names (synonym )：API4 IAP4
Gene names (ORF )：
Length：142
Mass：16389
Sequence：MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
Tissue specificity：Expressed only in fetal kidney and liver, and to lesser extent, lung and brain (PubMed:10626797). Abundantly expressed in adenocarcinoma (lung, pancreas, colon, breast, and prostate) and in high-grade lymphomas (PubMed:14741722, PubMed:16329164). Also expressed in various renal cell carcinoma cell lines (PubMed:10626797). Expressed in cochlea including the organ of Corti, the lateral wall, the interdental cells of the Limbus as well as in Schwann cells and cells of the cochlear nerve and the spiral ganglions (at protein level). Not expressed in cells of the inner and outer sulcus or the Reissner's membrane (at protein level) (PubMed:21364656, PubMed:20627126). {ECO:0000269|PubMed:10626797, ECO:0000269|PubMed:14741722, ECO:0000269|PubMed:16329164, ECO:0000269|PubMed:20627126, ECO:0000269|PubMed:21364656}.
Induction：Up-regulated by COMP. {ECO:0000269|PubMed:17993464}.
Developmental stage：Expression is cell cycle-dependent and peaks at mitosis. {ECO:0000269|PubMed:18591255}.
Protein families：IAP family