SL9B2_MOUSE Q5BKR2
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UniProt:Q5BKR2
Recommended name：Sodium/hydrogen exchanger 9B2
EC number：
Alternative names：(NHA-oc) (Na(+)/H(+) exchanger NHA2) (Na(+)/H(+) exchanger-like domain-containing protein 2) (NHE domain-containing protein 2) (Soditlum/hydrogen exchanger-like domain-containing protein 2) (Solute carrier family 9 subfamily B member 2)
Cleaved into：
GeneID：97086
Gene names (primary )：Slc9b2
Gene names (synonym )：Nha2 Nhedc2
Gene names (ORF )：
Length：547
Mass：58934
Sequence：MEDEDKTAECQHSKPPTGITHEAPPHHELQEERVMSLRGTDRSEPTEGSNLLTSGEKKPQDSPTEPNGLQSLRRFLACPPRGCLARVITNGTMVVLLWAMVWSVTGPECLPGGNLFGIIILFYCSITGGKLFGLIKFPTLPPLPPLLGMLLAGFLLRNIPVINDSVRIQHKWSSSLRSIALSVILVRAGLGLDSKALRKLKGVCVRLAMGPCIVEACASAILSHFLMGLPWQWGFILGFVVGAVSPAVVVPSMLLLQEGGYGVGKGIPTLLMAAGSFDDILAITGFNTCLGVAFSTGSTVFNIFRGILEVVIGVAAGSFLGFFIQYFPSRDQDNLVWKRAFLVLGFAVLAVFSSVYFSFPGSGGLCTLVMAFLAGMRWTDKKSEVEKVIAVTWDVFQPLLFGLIGAEVSIVSLRAETVGLCVATLSIAVLIRILTTFLMVCFAGFNIKEKIFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLAILITAPIGSLLIGLLGPRVLQKSEHRTEEEVQGETSAHIQRKPEDSITEA
Tissue specificity：Widely expressed (PubMed:18000046, PubMed:18508966, PubMed:17988971). However expression seems to be restricted to specific cell types within individual organs, e.g. osteoclasts in the bone, distal tubules of the kidney or beta-cells of Langerhans islets (PubMed:18508966, PubMed:17988971, PubMed:17698421, PubMed:23720317). In sperm specifically present in the principal piece of sperm tail (at protein level) (PubMed:27010853). {ECO:0000269|PubMed:17698421, ECO:0000269|PubMed:17988971, ECO:0000269|PubMed:18000046, ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:23720317, ECO:0000269|PubMed:27010853}.
Induction：Not detectable during the early stages of osteoclast differentiation induced by TNFSF11/RANKL (PubMed:17698421, PubMed:17988971). Up-regulated during the later stages of osteoclast differentiation (PubMed:20441802, PubMed:18508966, PubMed:17698421, PubMed:17988971). Up-regulated in macrophages and blood mononuclear cells treated with TNFSF11/RANKL. {ECO:0000269|PubMed:17698421, ECO:0000269|PubMed:17988971, ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:20441802}.
Developmental stage：
Protein families：Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family