EPIPL_MOUSE Q8R0W0
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UniProt:Q8R0W0
Recommended name：Epiplakin
EC number：
Alternative names：
Cleaved into：
GeneID：223650
Gene names (primary )：Eppk1
Gene names (synonym )：EPPK
Gene names (ORF )：
Length：6548
Mass：724646
Sequence：MNGQAPPHDVVVANGTEKFIVPKIKKNQLGASTPSRPQAEAALPTTARSIAGVYVEASGQTQSIYAAIKQGLLPTGLGLTLLEAQAATGGLVDLAQGQLLPVSEALRRGLVGLELKEKLLAAERAVTGYPDPYGGEKLSLFQAIKKEVVDRTLGWRLLEAQLATGGLVDPTQGVQVAPELACQQGLLDKETWLSLVESEPSMGTPGFSDPNTLEQLPYSVLLGRCVQDPSSGLPLLPLKTTFHTLAGAASASMLLEAGVLNEEMVRDLQEGMLVVSDVGTRPEVRRYLEGTGGLAGVVLLPGGHKKSFFQATVEHLVSKGIALQLLEAQAATRTLVHPTTGQRLWVEEAVKAGLVGPELHEQLLVAEQAVTGYYDPFSSSRIPVFQAMKKGLVDQPLALRLLDAQLATGGLICPARRFRLPLEAALRFGCLDEETRQRLSQAMGFSDPTTHDRLGYEQLLALSVTDPETGLAFLPLPGMSHANEPQGPTFIDHCTRQALSKATTSISVGRYQGRPVSLWELLFSESVPVKKRAMLAQRHQEGALSVEELAAELKNIVEQAAATAKVTFAGLRDTVTPGELLKAEIINQDLFEQLERGQTSAQDVGSLDSVQRYLQGTGSIAGLLLPDSQERLSIYEARSKGLLRPGTALILLEAQAATGFIIDPKENKRYSVEEALRAGVIGPDVYAKLLSAEHAVTGYTDPYSGEQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDQILNSILLDPSDDTKGFFDPNTHENLTYLQLLERCVHDSETGLHLLPLSSTRPQLVDSSTRQAFQKLLLSVKYGRFRGQRVSAWELVNSEYFTEDRRRQLLQRYRQRKITLEQVTQLLEKEMRRWTDITLPALQGQVTAYQLLEAHIINQELLDQVLTGTISPDALLQVGDVHRYLRGSGTVGGVLLKPSNQRISLYQAMKQKLLPPSTALALLEAQAATGTITDPCSMETLSVDEAVCRGVVGAEVYGKLKRAEHSITGYRDPFSGKKVSLFRAMKKGLVPVEQATRLLEAQVSTGGVVDPTTHLHLPMPVAVQRGCIDREMEAALSRSPETFPTPDGRGHTSYAQLLEHCLQDKASGLHLLPLTEDAPNVPTDTQIQETLQASAGTEDGLSLWDLLTSCHFTEEQRRGYLEDVKVGKISVPQLQNTVRSWVHSAKLLARARITVPGPRGEVPATWLRDAGIITQETLEALAQGMQSPDEVAKQPTVKVCLWGTGCVAGVLLQPSGTKLSIAQAVRDGLLPTGLGQQLLEAQVASGFLVNPLTNQRLSVEGAVKAGLVGMEQSEHLRQVEKAVTGYSDPFSGGSLSLWQAMEKGLVTQSEAFPLLQVQLATGGVVDPVHGVHLPQEVAYKLGLLDEQTSRVLTATGKENKLFFDPNSREKVTYQQLRELCVLDADTGLWLLPLPQGTVLEVDDHTAVALRAMKVPINMGRFQGHSVSLWDLLHSEYVGAEKRRELVALCCSGRAAALRQVIGMLTTLVEAAEKQPSQATFKGLRKQVSAGDLFRSQLITKQTLDELNQGKRTVQEVTEMDSVRRSLEGGNFIAGVLIQDTKEKMSIPEALRRHILRPGTALVLLEAQAATGFIIDPVENRKLTVEQAFQAGMFGKETYMKLLSAERAVTGYTDPYTGEQISLFQAMQRDLIVRDHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFNEEMNRILSDPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYMLEIVKKGETYTYIDEATRQALTSRTVKMYVGKFAGQTVSVWDLLSSQYFTEGRRRKLLREYRAQNIGLENLLEVITSTVEETEKQSQIFKVPGIHGDVTAAELFNSGILNKKTLDALRSGDRGFQDLRWLEDVRVYLEGSNYIAGVIAPLTQKVMSFYEASREELIPAGFAAQMLEAQAATGYLMDPCTNQRLCVDEAIAAGLVGEDLRERLVNAEMAAKGYKDPATGETIPLYQAMERKLVGREEALRLLEVQVATGGVIDPRHHHRVPLDTACQRGCMCDDSLVLIADQKHMRKRFVDPNTQEKVTYQELQDRCQREEKSGWALFPVVKDKKDIEYVDEATKRALEAEQVEVTVGRYRGQRRSVWELLNSEYVSEEKKMELVRLYKEDTTRALQKVVELILQMIADKERRSRQLWFRGLRTQVTAEELLRSEVITKQTLEDLEEGRTTVDQIERKEDVKRYLKGTSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRCYQAGGLTVHDVTTTLTSLLARAKDGSPRGDPQGALGKATMEVKRGHLRGHEVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPRXDPQGALGKATMEVKRGHLRGHXVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVRDHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDEDMNSILADPGDDTKGFFDPNTHENLTYLQLLRRCVRDPETGFYMLQLAGKGSSVHHLSEELRRALREARVTPGTGDFQGQSISVWELLFYREVPESLRQDLLRRYQAGGLTVHDVTTTLTSLLARAKDGSPREDPQGALGKATMEVKRGHLRGHVVPVWDILTSNYVSRDTRKELLAQFSSGSLTLPMLKRRLTTIIEEAEETQESKPKPRDASLKQQDTGARGSGTSPDEGDAQDSSESARQQQEQTLRATTMQVHRGQFRDQQVSVWKVLFSSYLSETRREELLAQHLAGKLGVMELVSLLTQIIEETEERLSKVSFPGLRRQVSASELCTSGILDRDTMRELAQGTKTIHEVTEMDSVKRYLGGSSCIAGVLVPVQGEPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFIIDPVNNRRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGDQISLFQAMQRDLIVKNHGIRLLEAQIATGGVIDPVHSHRVPVDVAYQRGYFDQEMNSILADPGDDTKGFFDPNTHENLTYLQLLQRATIDPETGLLFLSLSKG
Tissue specificity：High levels in skin, small intestine and salivary gland. Lower levels in lung, uterus and liver. Not detected in brain, kidney, muscle, heart or spleen. In skin, expressed in all epidermal layers but not in the dermis. In intestine, expressed exclusively in the epithelial cell layer of the villi. In liver, expressed at hepatocyte margins. Around the region of the wound, expressed in the upper half of the epidermis. Weakly expressed on the basilar side of the suprabasal layer of the epidermis at the wound's edge. Expressed strongly in the upper layer of the epidermis, especially in larger keratinocytes (PubMed:16382146). Expressed in undifferentiated primary keratinocytes (PubMed:18285451). Strongly expressed in ductal cells, and also expressed in acinar cells (PubMed:25232867). Expressed in hepatocytes and cholangiocytes (PubMed:25617501). {ECO:0000269|PubMed:12791695, ECO:0000269|PubMed:16382146, ECO:0000269|PubMed:18285451, ECO:0000269|PubMed:25232867, ECO:0000269|PubMed:25617501}.
Induction：Up-regulated upon calcium-mediated keratinocyte differentiation (PubMed:18285451). Up-regulated in hepatocytes during liver stress (PubMed:25617501). {ECO:0000269|PubMed:18285451, ECO:0000269|PubMed:25617501}.
Developmental stage：
Protein families：Plakin or cytolinker family