OAS1A_MOUSE P11928
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UniProt:P11928
Recommended name：2'-5'-oligoadenylate synthase 1A
EC number：EC 2.7.7.84
Alternative names：((2-5')oligo(A) synthase 1A) (2-5A synthase 1A) (p42 OAS)
Cleaved into：
GeneID：246730
Gene names (primary )：Oas1a
Gene names (synonym )：Oias1
Gene names (ORF )：
Length：367
Mass：42429
Sequence：MEHGLRSIPAWTLDKFIEDYLLPDTTFGADVKSAVNVVCDFLKERCFQGAAHPVRVSKVVKGGSSGKGTTLKGKSDADLVVFLNNLTSFEDQLNRRGEFIKEIKKQLYEVQHERRFRVKFEVQSSWWPNARSLSFKLSAPHLHQEVEFDVLPAFDVLGHVNTSSKPDPRIYAILIEECTSLGKDGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQLCKEKLGKPLPPQYALELLTVFAWEQGNGCYEFNTAQGFRTVLELVINYQHLRIYWTKYYDFQHQEVSKYLHRQLRKARPVILDPADPTGNVAGGNPEGWRRLAEEADVWLWYPCFIKKDGSRVSSWDVPTVVPVPFEQVEENWTCILL
Tissue specificity：Expressed in oocytes and granulosa cells of ovary, in intestine, stomach, spleen and uterus (at protein level) (PubMed:15899864). Expressed at high levels in the digestive tract and lymphoid organs (PubMed:12396720). Expressed in ovary and spleen (PubMed:27663720). {ECO:0000269|PubMed:12396720, ECO:0000269|PubMed:15899864, ECO:0000269|PubMed:27663720}.
Induction：Up-regulated in response to the type I interferon IFNB1, in a STAT1 and STAT2-dependent manner (PubMed:1709495, PubMed:22305621). Induced by polyinosinic:polycytidylic acid (poly I:C) (PubMed:15899864, PubMed:27663720). {ECO:0000269|PubMed:15899864, ECO:0000269|PubMed:1709495, ECO:0000269|PubMed:22305621, ECO:0000269|PubMed:27663720}.
Developmental stage：Detected 5 weeks after birth in developing ovary and spleen (PubMed:27663720). Expressed in fully grown, germinal vesicle (GV)-intact oocytes, in oocytes at the metaphase II stage and in the 2- to 8-cell embryos (PubMed:15899864). {ECO:0000269|PubMed:15899864, ECO:0000269|PubMed:27663720}.
Protein families：2-5A synthase family