ZFHX2_MOUSE Q2MHN3
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UniProt:Q2MHN3
Recommended name：Zinc finger homeobox protein 2
EC number：
Alternative names：(Zinc finger homeodomain protein 5)
Cleaved into：
GeneID：239102
Gene names (primary )：Zfhx2
Gene names (synonym )：Kiaa1056 zfh-5
Gene names (ORF )：
Length：2562
Mass：273485
Sequence：MATLNSASPSGTVPSPGHNVRSPPPETSSSSTSDPVTKDPPDAPSTSESIRSSEPGGERLESGSDLDPPKEIGEPQEEPGCGHIPPKDLGVAKEEEEILPLDLSSHLFFAAGGQAYLLANLPLPRGSELSLPKGFPWDEASAKEEPSLPLLTHFPSSHLTTLHIQHGFDPIQGFSSSDQMLSHDTSAPSLAACERRDGSFWSYQLVPNPTEDPKDGPLGSRREDHRAMFWICLLCRLGFGRLQTFIGHTLSHGVKLSPAHHQGLLGSPAVLQEGHDGGMALLSFLEPKFLTRPSPEVPDTSTVTVKTNGAQAEDGPPEADGQALVLPAEEVIALSPPSPPTALATWDPSPTQAKDSPVPRGEAGPDWFPEGQEEDGGLCLPLNQSSPTSKEVAVLPAPAGSPEDTSDPPPSCRLADDYTPAPAAFQGLSLSSHMSLLHSRNSCKTLKCPKCNWHYKYQQTLDVHMREKHPESNSHCSYCSAGGAHPRLARGESYNCGYKPYRCDVCNYSTTTKGNLSIHMQSDKHLANLQGFQAGPGGQASPPEASLPPTSVGDKEPKTKSSWQCKVCSYETNISRNLRIHMTSEKHMQNVLMLHQGLPLGLPPGLVGPGPPPPPGAAPTNPPELFQYFGPQALGQPQTPMPGPGLRPDKPLEAQLLLNGFHHLGAPARKFPTAAPGSLSPETHLPPSQLLGSSSDGLPTSPSPDDSPALKVFRCLVCQAFSTDSLELLLYHCSIGRSLPEAEWKEVAGDTHRCKLCCYGTQLKANFQLHLKTDKHTQKYQLAAHLREGGGAMGTPSLLALGDGASYGSISPLHLRCNICDFESNSKEKMQLHTRGSAHEENSQIYKFLLEMEGAEAGPEPGLYHCLLCAWDTPSRLALLQHLRTPAHRDAQAQRRLQLLQNGPAAEEGLSALQSILSFSHGRLQTPGKASDTPLAQPPTSEKDAQNKTEQQASEVTEDRSGPPRDSANQITVFCCPYCSFLSPECDQVRVHTLSQHAVQPKYRCPLCQEQLVGRPALHFHLSHLHNVVPECVEKLLLVATTVEMTFATKMLPGPTLNPVEDGLDHPAPGAEPTPNRDQVAESSNLAPEVSPDPPLEPPLAPVEGSREPSESPDQPPSPAPSPAPRLDAQVEELAPLPTMSEEEEGAMGEPRSAEPTPADSRHPLTYRKTTNFALDKFLDPARPYKCTVCKESFTQKNILLVHYNSVSHLHKMKKAAIDPSGPARGEAGIPPPAATASDKPFKCTVCRVSYNQSSTLEIHMRSVLHQTRSRGAKIDARAEGAERGQEEFKEGETEGEAGTEKKGPDPGGFMSGLPFLSPPPPPLDLHRFSAPLFTPPVLPPFPLVPESLLKLQQQQLLLPFYLHDLKVGPKLALASPTPMLSLPAANPPPLPAPPKAELAEQEWERPLMAEEGTEAGPSSPTHTSPNEAARTAAKALLENFGFELVIQYNEGKQAVPPPPTPPPPESLGGGDKLACGACGKLFSNMLILKTHEEHVHRRFLPFEALSRYAAQFRKSYDSLYPPPVEPPKPPDGCLESPPQLGPPFVVPEPEVGGIHTSEERSLSGGGPWPSEEEEGSRGSLPPAVPVGRRFSRTKFTEFQTQALQSFFETSAYPKDGEVERLASLLGLASRVVVVWFQNARQKARKNACEGGPVTAGGASGGASGCRRCHATFACVFELVRHLKKCYDDQPPEEEEEAERGEEEEEVEEEEAEERNLEPAAARPGGPSPEHADGEDLSQTEPTRPESKESEGKAPPSPPVYACDQCAASFPSQDLLTTHHRLHLLPSVQPSAPPPSQLLDLPLLVFGERNPVVSGTSSVTGTPLKRKHDDGSLSPTGSEAGGGGEGEPPKDKRLRTTILPEQLEILYRWYMQDSNPTRKMLDCISEEVGLKKRVVQVWFQNTRARERKGQFRSTPGGVAGPAVKPTVPPSPAPFPKFNLLLSKIEDETGKEAPKRDAPAFPYPTVTPAVGPLPFLPPGKEAAVPTPEPPPPLPPPALSEDEGPEEPSKASPESEACSPSAGDLSDSSASSLAEPESPGAGGTSGGPGGGTGVPDSMGQRRYRTQMSSLQLKIMKACYEAYRTPTMQECEVLGEEIGLPKRVIQVWFQNARAKEKKAKLQGTAPPGSGGSSEGTSAAQRTDCPYCDVKYDFYVSCRGHLFSRQHLAKLKEAVRAQLKSESKCYDLAPAPETPLAPKGPPATTPASSVPLGASPTLPRLAPVLLPGPTLAQPPLGSIASFNSGPAASSGLLGLATSVLPATTVVQTAGPGRPLPQRPVSNQTNSSTDPTPGPATEPSGDKVSGERKPVATLPNSSTDALKNLKALKATVPALLGGQFLPFPLPPAGGAAPPAVFGPQLQGAYFQQLYGMKKGLFPMNPVIPQTLIGLLPNALLQQPPQAPEPTATAPPKPPELPASGEGESSEADELLTGSTGISTVDVTHRYLCRQCKMAFDGEAPATAHQRSFCFFGRGSGASMPAPLRVPICTYHCLACEVLLSGREALASHLRSSAHRRKAAPPPGGPPITVTNSATAVPAAVAFAKEEARLPHTDPNPKTTTTSTLLAL
Tissue specificity：Expressed in brain (at protein level) (PubMed:23300874). Expressed at the highest levels in the pyramidal cell layer of the hippocampus, the suprachiasmatic nucleus, laterodorsal thalamic nucleus, lateral geniculate nucleus, substantia nigra pars compacta, and magnocellular part of the red nucleus (at protein level) (PubMed:23300874). Highly expressed in dorsal root ganglia (PubMed:29253101). Expressed at lower levels in kidney, stomach, liver, heart and testis (PubMed:16257534, PubMed:23300874). {ECO:0000269|PubMed:16257534, ECO:0000269|PubMed:23300874, ECO:0000269|PubMed:29253101}.
Induction：Expression in specific regions of the developing brain is negatively regulated by its antisense mRNA. In particular, down-regulated in pyramidal and granule cells in the hippocampus during early differentiation and the migration stage. {ECO:0000269|PubMed:16257534}.
Developmental stage：Detected at 11.5 days post coitum (dpc) in developing brain, and continues to be expressed all the way through to postnatal day 21 (PubMed:23300874). In brain, expressed at 13.5 dpc in thalamus, hypothalamus, midbrain and pontine area (PubMed:16257534). {ECO:0000269|PubMed:16257534, ECO:0000269|PubMed:23300874}.
Protein families：