KCNK1_MOUSE O08581
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UniProt:O08581
Recommended name：Potassium channel subfamily K member 1
EC number：
Alternative names：(Inward rectifying potassium channel protein TWIK-1)
Cleaved into：
GeneID：16525
Gene names (primary )：Kcnk1
Gene names (synonym )：
Gene names (ORF )：
Length：336
Mass：38201
Sequence：MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDLVHIMEHDQLSFSSVTEQVAGLKEEQKQSEPFVASQSPPYEDGSADH
Tissue specificity：Detected in spiral ganglion neurons (PubMed:17079103). Detected in hippocampus CA1 and CA1 regions and in the molecular layer of the dentate gyrus (PubMed:24368895, PubMed:25406588). Detected on hippocampus astrocytes (PubMed:24368895, PubMed:24496152). Highly expressed in the stria vascularis in the cochlea (PubMed:12855359). Detected in pancreas islet beta cells (PubMed:22431633). Detected in kidney, at brush border membranes in proximal tubules and in cytoplasmic structures in distal convoluted tubules, thick ascending limbs and collecting ducts (at protein level) (PubMed:15540117, PubMed:16025300). Widely expressed. Detected in spiral ganglion cells (PubMed:17079103). Highest expression in brain, kidney, thyroid, salivary gland, adrenal gland, prostate, epididymis, uterus, placenta, colon and jejunum. Moderate expression in eyes, pituitary, pancreas, smooth muscle, testis and ovary. Very low levels in lung, aorta, liver, heart, skeletal muscle, thymus and spleen. In the brain, highest expression in cerebellar granule cells, brainstem, hippocampus and cerebral cortex (PubMed:18222039). {ECO:0000269|PubMed:15540117, ECO:0000269|PubMed:16025300, ECO:0000269|PubMed:18222039, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:24368895, ECO:0000269|PubMed:25406588, ECO:0000269|PubMed:9013852, ECO:0000269|PubMed:9559671}.
Induction：
Developmental stage：Detected at very low levels in the embryonic central nervous system (PubMed:9559671, PubMed:18222039). Detected as early as 7 days post conception (PubMed:9559671). Detected in dorsal root ganglia, hippocampus, olfactory epithelia and intestine at 19 dpc (PubMed:18222039). Expression in the brain increases strongly 3-8 days after birth, a period of intense postnatal brain development (PubMed:9559671, PubMed:18222039). Detected in dentate granule cells; expression levels show no significant variability during postnatal development (PubMed:18222039). Expression is higher in adults than in neonates (PubMed:9559671, PubMed:18222039). {ECO:0000269|PubMed:18222039, ECO:0000269|PubMed:9559671}.
Protein families：Two pore domain potassium channel (TC 1.A.1.8) family