AUTS2_MOUSE A0A087WPF7
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UniProt:A0A087WPF7
Recommended name：Autism susceptibility gene 2 protein homolog
EC number：
Alternative names：
Cleaved into：
GeneID：
Gene names (primary )：Auts2
Gene names (synonym )：Kiaa0442
Gene names (ORF )：
Length：1261
Mass：138920
Sequence：MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGAGRTRAPSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEALEKDVAVKPQERAEKRQTPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQHLGKRKKMPKGLRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQAQAEPQLQIPSPGPDLVPRTEAPPQFPPPSTQPAQGPPEAQLQPAPLPQVQQRPPRPQSPSHLLQQTLPPVQSHPSSQSLSQPLSAYNSSSLSLNSLSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSPAPPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYENPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR
Tissue specificity：Detected in brain cortex in embryo, neonates and adults (at protein level) (PubMed:19948250, PubMed:25533347, PubMed:25519132). Detected in embryonic and adult Purkinje cells in the cerebellum (PubMed:19948250). Detected in dorsal thalamus and in dopaminergic neurons in substantia nigra (PubMed:19948250). {ECO:0000269|PubMed:19948250, ECO:0000269|PubMed:25519132, ECO:0000269|PubMed:25533347}.
Induction：
Developmental stage：Detected in embryonic brain cortex at 15 dpc, and at clearly lower levels in adult brain cortex, hippocampus and in cerebellum Purkinje cells (at protein level) (PubMed:25519132). Very low and barely detectable in embryonic brain at 11 dpc. Detected in the developing brain cortex, thalamus and cerebellum at 12 and 14 dpc. Uniformly expressed all along the preplate at 13 dpc. At 16 dpc, highly expressed in neurons in deep and superficial layers of the frontal cortical region of the preplate, with much lower expression in the caudal region or the preplate. Highly expressed in thalamus at 14 dpc, and at much lower levels in adults. Highly expressed in hippocampus after 13 dpc; expression levels increase subsequently and are high in dentate gyrus and the CA region of the hippocampus at 19 dpc. Expression in dentate gyrus, granule cell layer and the CA region of the hippocampus continues in neonates and into adulthood. {ECO:0000269|PubMed:19948250}.
Protein families：AUTS2 family