CI072_MOUSE Q6DFW0
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UniProt:Q6DFW0
Recommended name：Guanine nucleotide exchange C9orf72 homolog
EC number：
Alternative names：
Cleaved into：
GeneID：73205
Gene names (primary )：
Gene names (synonym )：
Gene names (ORF )：
Length：481
Mass：54278
Sequence：MSTICPPPSPAVAKTEIALSGESPLLAATFAYWDNILGPRVRHIWAPKTDQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIVLEGTERMEDQGQSIIPMLTGEVIPVMELLASMKSHSVPEDIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDATGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFHLKPGLSLRSTFLAQFLLILHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMTF
Tissue specificity：Expressed in postnatal cerebellum and cortex (at protein level). Neuronal expression is detected in several regions of the adult brain and spinal cord (PubMed:26044557). Prominent expression also observed in embryonic and early postnatal neurons including retinal ganglion cells, sensory neurons in the olfactory epithelium and in dorsal root ganglia, and spinal motor neurons (PubMed:26044557). Expressed in the developing cerebral cortex, cerebellum, olfactory bulb, hippocampus and spinal cord in the embryo and in P0 cortical neurons and astrocytes (PubMed:27476503). Also expressed in non-neuronal tissues such as kidney and tooth (PubMed:26044557). In the spleen, highly expressed in myeloid cells compared to B cell and T cell populations where expression is much lower (PubMed:26989253). In the brain, highly expressed in microglia (PubMed:26989253). {ECO:0000269|PubMed:26044557, ECO:0000269|PubMed:26989253, ECO:0000269|PubMed:27476503}.
Induction：
Developmental stage：Expressed in cerebral cortex and hippocampus at embryonic day 18 and postnatal days 1, 7, 14, 28 and 56. {ECO:0000269|PubMed:26408000}.
Protein families：