ZAP70_MOUSE P43404
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UniProt:P43404
Recommended name：Tyrosine-protein kinase ZAP-70
EC number：EC 2.7.10.2
Alternative names：(70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Cleaved into：
GeneID：22637
Gene names (primary )：Zap70
Gene names (synonym )：Srk Zap-70
Gene names (ORF )：
Length：618
Mass：70112
Sequence：MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCQFYSQDPDGLPCNLRKPCNRPPGLEPQPGVFDCLRDAMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAAVAAPTLPAHPSTFTQPQRRVDTLNSDGYTPEPARLASSTDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLLGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFLTVEQRMRNYYYSLASRAEGPPQCEQVAEAACG
Tissue specificity：Isoform 1 and isoform 2 are expressed in thymus, spleen and lymph nodes. {ECO:0000269|PubMed:14985102}.
Induction：
Developmental stage：Isoform 2 is expressed in developing thymocytes from the CD44+CD25- stage up to mature T-cells. Isoform 1 is not expressed in thymocytes at the CD44+CD25- or CD44+CD25+ stages. {ECO:0000269|PubMed:14985102}.
Protein families：Protein kinase superfamily, Tyr protein kinase family, SYK/ZAP-70 subfamily