ZHX2_MOUSE Q8C0C0
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UniProt:Q8C0C0
Recommended name：Zinc fingers and homeoboxes protein 2
EC number：
Alternative names：(Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2)
Cleaved into：
GeneID：387609
Gene names (primary )：Zhx2
Gene names (synonym )：Afr1 Raf
Gene names (ORF )：
Length：836
Mass：92259
Sequence：MASKRKSTTPCMVRTSQVLEQDMLEEADRAKDKGAGMPQSDVTKDSWAAEPEHSSKETEVVEVKSMGENLSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATNHVVPITASGPGSSDNDPGVSVGKTPMTKTGKLKADAKKVPKKPDEAAPENHMEGTARLVTDTAEILARLGSVELLQDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQMAITGTRHGRTYHVYPDFAPQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDAVAPNGALSRLDQLSGAQLAGSLPSPSSAIVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTLSWLEQYQRHHMSDDRGRDAVSRKVAKQVAESPKNGSEAAHQYAKDPKALSEEDSEKLVPRMKVGGDPTKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVGEEDAISEKWGSWSRRVAEGTVERADSDSDSTPAEAGQA
Tissue specificity：Expressed in retina where it localizes to Muller glial cells of the inner nuclear layer (at protein level) (PubMed:30146259). Detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis (PubMed:14659886). {ECO:0000269|PubMed:14659886, ECO:0000269|PubMed:30146259}.
Induction：
Developmental stage：Strongly expressed in retina from embryonic stages 14.5 dpc to 17.5 dpc, where it is widely detected in retinal progenitor cells (at protein level) (PubMed:30146259). Expression then gradually declines and stabilizes at a low level by postnatal day 10 (P10) (at protein level) (PubMed:30146259). At P0, expression refines to the inner half of the neuroblastic layer (at protein level) (PubMed:30146259). Expression further refines to the retinal inner nuclear layer from stage P3 onwards (at protein level) (PubMed:30146259). Detected in bipolar OFF-type cells at stage P7 (at protein level) (PubMed:30146259). By stage P10, has only weak expression in bipolar OFF-type cells but strong expression in Muller glial cells (at protein level) (PubMed:30146259). Detected in brain at embryonic stages 12.5 dpc to 15.5 dpc, specifically in the ventricular zone and subventricular zone of the cortex (at protein level) (PubMed:19515908). Probably localizes to neural progenitor cells in the developing cortex (at protein level) (PubMed:19515908). {ECO:0000269|PubMed:19515908, ECO:0000269|PubMed:30146259}.
Protein families：ZHX family