Product List

Phospho-Rb (Ser807) Rabbit Monoclonal Antibody

Size:50μL Price:$168
Size:100μL Price:$300
Size:200μL Price:$520
Application:WB,IHC,ICC/IF
Reactivity:Human, Mouse, Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:RB1

SKU: AMRe03902

Detail

Summary

Production Name	Phospho-Rb (Ser807) Rabbit Monoclonal Antibody
Description	Recombinant rabbit monoclonal antibody
Host	Rabbit
Application	WB,IHC,ICC/IF
Reactivity	Human, Mouse, Rat

Performance

Conjugation	Unconjugated
Modification	Phosphorylated
Isotype	IgG
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Liquid in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% protective protein.
Purification	Affinity Purification

Immunogen

Gene Name	RB1
Alternative Names	RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Gene ID	5925
SwissProt ID	P06400

Application

Dilution Ratio	WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200
Molecular Weight	Calculated MW:106 kDa;Observed MW: 110 kDa

Background

Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.

Research Area

Cell Biology