NMDAR2A Rabbit Monoclonal Antibody

NMDAR2A Rabbit Monoclonal Antibody

Size1:50μl Price1:$158
Size2:100μl Price2:$288
Size3:500μl Price3:$1200
SKU: AMRe03787 Category: Rabbit Monoclonal Antibody Tags: , , ,

Datasheet

Summary

Production Name

NMDAR2A Rabbit Monoclonal Antibody

Description

Recombinant Rabbit Monoclonal antibody

Host

Rabbit

Application

WB

Reactivity

Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Unmodified

Isotype

IgG

Clonality

Monoclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification

Affinity Purified

 

Immunogen

Gene Name

Grin2A

Alternative Names

NR2A; GluN2A; NMDAR2A; GluRepsilon1

Gene ID

14811

SwissProt ID

P35436

 

Application

Dilution Ratio

WB: 1/500-1/1000

Molecular Weight

Calculated MW: 165 kDa; Observed MW: 165 kDa

 

Background

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+. Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B . Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.

 

Research Area

Neuroscience