Name: XRCC4 (7C10) Mouse Monoclonal Antibody
Brand: Enkilife Limited
SKU: AMM03579
Price: 150 USD
Availability: InStock
Rating: 5 (1 reviews)

XRCC4 (7C10) Mouse Monoclonal Antibody

Size:50μL Price:$150
Size:100μL Price:$280
Size:200μL Price:$520
Application:WB,IHC,ICC/IF,IP
Reactivity:Human,Mouse,Rat
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:XRCC4

SKU: AMM03579

Detail

Summary

Production Name	XRCC4 (7C10) Mouse Monoclonal Antibody
Description	Mouse monoclonal Antibody
Host	Mouse
Application	WB,IHC,ICC/IF,IP
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG1
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3.
Purification	Affinity Purification

Immunogen

Gene Name	XRCC4
Alternative Names	X ray repair cross complementing protein 4; DNA repair protein XRCC4; DNA double strand break repair
Gene ID	7518
SwissProt ID	Q13426

Application

Dilution Ratio	WB 1:500-1:1000,IHC 1:50-1:100,ICC/IF 1:50-1:200,IP 1:20-1:50
Molecular Weight	Calculated MW: 38 kDa; Observed MW: 38-45 kDa

Background

Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Research Area

Epigenetics and Nuclear Signaling