Name: Ku70 (7B1) Mouse Monoclonal Antibody
Brand: Enkilife Limited
SKU: AMM03519
Price: 168 USD
Availability: InStock
Rating: 5 (1 reviews)

Ku70 (7B1) Mouse Monoclonal Antibody

Size:50μL Price:$168
Size:100μL Price:$300
Size:200μL Price:$520
Application:WB,ICC/IF,IP,ChIP
Reactivity:Human,Monkey
Conjugate:Unconjugated
Optional conjugates: Biotin, FITC (free of charge). See other 26 conjugates.
Gene Name:XRCC6

SKU: AMM03519

Detail

Summary

Production Name	Ku70 (7B1) Mouse Monoclonal Antibody
Description	Mouse monoclonal Antibody
Host	Mouse
Application	WB,ICC/IF,IP,ChIP
Reactivity	Human,Monkey

Performance

Conjugation	Unconjugated
Modification	Unmodified
Isotype	IgG1
Clonality	Monoclonal
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Liquid in PBS containing 50% glycerol, 0.5% protective protein and 0.02% sodium azide, pH 7.3.
Purification	Affinity Purification

Immunogen

Gene Name	XRCC6
Alternative Names	XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-
Gene ID	2547
SwissProt ID	P12956

Application

Dilution Ratio	WB 1:500-1:1000,ICC/IF 1:50-1:200,IP 1:20-1:50,ChIP 1:20
Molecular Weight	Calculated MW: 70 kDa; Observed MW: 67 kDa

Background

It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.

Research Area

Epigenetics and Nuclear Signaling