Cleaved-Notch1 Rabbit Polyclonal Antibody

Cleaved-Notch1 Rabbit Polyclonal Antibody

Size1:50μl Price1:$168
Size2:100μl Price2:$300
Size3:500μl Price3:$1200 SKU: APRab00818 Category: Polyclonal Antibody Tags: , , , ,

Datasheet

Summary

Production Name

Cleaved-Notch1 Rabbit Polyclonal Antibody

Description

Primary antibody

Host

Rabbit

Application

WB,ELISA

Reactivity

Human,Mouse,Rat

 

Performance

Conjugation

Unconjugated

Modification

Cleaved

Isotype

IgG

Clonality

Polyclonal Antibody

Form

Liquid

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification

Affinity Purified

 

Immunogen

Gene Name

NOTCH1

Alternative Names

NOTCH1; TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1

Gene ID

4851

SwissProt ID

P46531

 

Application

Dilution Ratio

WB: 1/500-1/1000 ELISA: 1/10000

Molecular Weight

Calculated MW: 273 kDa; Observed MW: 110 kDa

 

Background

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

 

Research Area

Neuroscience

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