Summary
Performance
Immunogen
Application
Background
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008],domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds as a monomer with high affinity to interleukin 13 (IL13), but not to IL4.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,similarity:Contains 1 fibronectin type-III domain.,
Research Area
Jak_STAT;
