ARC_RAT Q63053
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UniProt:Q63053
Recommended name：Activity-regulated cytoskeleton-associated protein 1 Publication
EC number：
Alternative names：
Cleaved into：
GeneID：54323
Gene names (primary )：Arc 1 Publication
Gene names (synonym )：
Gene names (ORF )：
Length：396
Mass：45,353
Sequence：MELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRRTHRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREMHVWREVFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQEADGYDYTVSPYAITPPPAAGELPEQESVGAQQYQSWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKFKRFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSVTPLPTEDETEALTPALTSESVASDRTQPE
Tissue specificity：Expressed exclusively in certain parts of the brain including cortex and molecular layer of the hippocampus. Typically expressed at high level in a minority of neurons. Basal expression higher in cortex than in hippocampus, highest in visual cortex. 2 s
Induction：Expressed during postnatal development from day 8 (PubMed:7857651). Highest expression around day 23 with moderate levels expressed to adulthood (PubMed:7857651). 1 Publication
Developmental stage：Arc expression is regulated at transcription, post-transcription and translation levels (PubMed:10570490, PubMed:11226315, PubMed:18614031, PubMed:9808461). Transcription is tightly coupled to encoding of information in neuronal circuits (PubMed:10570490). Expression is induced by neuronal and synaptic activity (PubMed:10570490, PubMed:7777577, PubMed:7857651). Induced at highest level in hippocampus within 30 minutes, dropping to basal levels within 24 hours (PubMed:7777577, PubMed:7857651). Arc transcripts are transported to dendrites and become enriched at sites of local synaptic activity where they are locally translated into protein (PubMed:18614031, PubMed:9808461). Arc transcripts resemble some viral RNAs and contain an internal ribosomal entry site (IRES) that allows cap-independent translation (PubMed:11226315). 6 s
Protein families：ARC/ARG3.1 family