GASR_HUMAN P32239
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UniProt:P32239
Recommended name：Gastrin/cholecystokinin type B receptor
EC number：
Alternative names：(CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R)
Cleaved into：
GeneID：887
Gene names (primary )：CCKBR
Gene names (synonym )：CCKRB
Gene names (ORF )：
Length：447
Mass：48419
Sequence：MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
Tissue specificity：Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269|PubMed:10913157, ECO:0000269|PubMed:12429993, ECO:0000269|PubMed:7848914, ECO:0000269|PubMed:7887934, ECO:0000269|PubMed:8185170, ECO:0000269|PubMed:8349705}.
Induction：
Developmental stage：
Protein families：G-protein coupled receptor 1 family