GFI1B_HUMAN Q5VTD9
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UniProt:Q5VTD9
Recommended name：Zinc finger protein Gfi-1b
EC number：
Alternative names：(Growth factor independent protein 1B) (Potential regulator of CDKN1A translocated in CML)
Cleaved into：
GeneID：8328
Gene names (primary )：GFI1B
Gene names (synonym )：
Gene names (ORF )：
Length：330
Mass：37492
Sequence：MPRSFLVKSKKAHTYHQPRVQEDEPLWPPALTPVPRDQAPSNSPVLSTLFPNQCLDWTNLKREPELEQDQNLARMAPAPEGPIVLSRPQDGDSPLSDSPPFYKPSFSWDTLATTYGHSYRQAPSTMQSAFLEHSVSLYGSPLVPSTEPALDFSLRYSPGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK
Tissue specificity：Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA). {ECO:0000269|PubMed:12351384, ECO:0000269|PubMed:17156408, ECO:0000269|PubMed:9878267}.
Induction：By GATA1 which binds to GFI1B promoter in cooperation with the transcription factor NFYA. Target gene of transcription factor E2-alpha/TCF3 that promotes growth arrest and apoptosis in lymphomas. {ECO:0000269|PubMed:15280509}.
Developmental stage：
Protein families：