DDIT4_HUMAN Q9NX09
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UniProt:Q9NX09
Recommended name：DNA damage-inducible transcript 4 protein
EC number：
Alternative names：(HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
Cleaved into：
GeneID：54541
Gene names (primary )：DDIT4
Gene names (synonym )：REDD1 RTP801
Gene names (ORF )：
Length：232
Mass：25371
Sequence：MPSLWDRFSSSSTSSSPSSLPRTPTPDRPPRSAWGSATREEGFDRSTSLESSDCESLDSSNSGFGPEEDTAYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLAQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVGQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLFSSANSPFLPGFSQSLTLSTGFRVIKKKLYSSEQLLIEEC
Tissue specificity：Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level). {ECO:0000269|PubMed:11884613, ECO:0000269|PubMed:12453409, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067}.
Induction：Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism (at protein level). {ECO:0000269|PubMed:11884613, ECO:0000269|PubMed:12453409, ECO:0000269|PubMed:14646594, ECO:0000269|PubMed:15592522, ECO:0000269|PubMed:15751966, ECO:0000269|PubMed:17379067, ECO:0000269|PubMed:20166753}.
Developmental stage：
Protein families：DDIT4 family