M3K8_HUMAN P41279
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UniProt:P41279
Recommended name：Mitogen-activated protein kinase kinase kinase 8
EC number：EC:2.7.11.25
Alternative names：(Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
Cleaved into：
GeneID：1326
Gene names (primary )：MAP3K8
Gene names (synonym )：COT ESTF
Gene names (ORF )：
Length：467
Mass：52925
Sequence：MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
Tissue specificity：Expressed in several normal tissues and human tumor-derived cell lines.
Induction：Up-regulated by IL12 in T-lymphocytes. Up-regulated in subcutaneous adipose tissue of obese individuals. {ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}.
Developmental stage：Isoform 1 is activated specifically during the S and G2/M phases of the cell cycle.
Protein families：Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily