KMT2C_MOUSE Q8BRH4
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UniProt:Q8BRH4
Recommended name：Histone-lysine N-methyltransferase 2C
EC number：EC 2.1.1.354
Alternative names：(Lysine N-methyltransferase 2C) (Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog)
Cleaved into：
GeneID：
Gene names (primary )：Kmt2c
Gene names (synonym )：Mll3
Gene names (ORF )：
Length：4903
Mass：540187
Sequence：MSSEEDRSAEQQQPPPAPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKSTVEDEDSMDGLETTETENIVETEIKEQSVEEDAETEVDSSKQPVSALQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRVTPGLTLPWKDQPSNKDIDDNSSGTCEKIQNYAPRKQRGQRKERPPQQSAVSCVSVSTQTACEDQAGKLWDELSLVGLPDAIDVQALFDSTGTCWAHHRCVEWSLGICQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHFFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSTQWHHNCLICDTCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDQELDSQLKEDYICMYCKHLGAEIDPLHPGNEVEMPELPTDYASGMEIEGTEDEVVFLEQTVNKDVSDHQCRPGIVPDVQVYTEEPQKSNPLESPDTVGLITSESSDNKMNPDLANEIAHEVDTEKTEMLSKGRHVCEEDQNEDRMEVTENIEVLPHQTIVPQEDLLLSEDSEVASKELSPPKSAPETAAPEALLSPHSERSLSCKEPLLTERVQEEMEQKENSEFSTGCVDFEMTLAVDSCDKDSSCQGDKYVELPAEEESTFSSATDLNKADVSSSSTLCSDLPSCDMLHGYPPAFNSAAGSIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSNHNTVSPPSWAPDTSEGREIFKPRQLSGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGIGAVVLPGVSAADISSNKDEEENSMHNTVVLFSSSDKFTLQQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCCRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPVSNVPSSDCCDSSLVAQIVTKVKELDPPKTYTQDGVCLTESGMSQLQSLTVTAPRRKRTKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAGDDETKGIEGTDAIKKRKRKPYRPGIGGFMVRQRSRTGQGKAKRSVVRKDSSGSISEQLPSRDDGWREQLPDTLVDEPVSVAENTDKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQNKLSVDNLSEDAAQLSFKTGFLDPSSDPLLSSSSTSAKPGTQGTADDPLADISEVLNTDDDILGIISDDLAKSVDHSDIGPTTADASSLPQPGVSQSSRPLTEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPATTQPAPLPQPPPPPQLLPMHNQDVFSRMPLMNGLIGPSPHLPHNSLPPGSGLGTFPAIAQSPYTDVRDKSPAFNAIASDPNSSWAPTTPSMEGENDTLSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSDLFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQQQQQQQQLASQHLLVAPGSDTPSSGAQSPLTPQAGNGNVSPAQTFHKDLFSKHLPGTPASTPSDGVFVKPQPPPPPSTPSRIPVQESLSQSQNSQPPSPQMFSPGSSHSRPPSPVDPYAKMVGTPRPPPGGHSFPRRNSVTPVENCVPLSSVPRPIHMNETSATRPSPARDLCASSMTNSDPYAKPPDTPRPMMTDQFSKPFSLPRSPVISEQSTKGPLTTGTSDHFTKPSPRTDAFQRQRLPDPYAGPSLTPAPLGNGPFKTPLHPPPSQDPYGSVSQTSRRLSVDPYERPALTPRPVDNFSHSQSNDPYSHPPLTPHPAMTESFTHASRAFPQPGTISRSASQDPYSQPPGTPRPLIDSYSQTSGTARSNPDPYSQPPGTPRPNTIDPYSQQPPTPRPSPQTDMFVSSVANQRHTDPYTHHLGPPRPGISVPYSQPPAVPRPRTSEGFTRPSSARPALMPNQDPFLQAAQNRVPGLPGPLIRPPDTCSQTPRPPGPGRIDTFTHASSSAVRDPYDQPPVTPRPHSESFGTSQVVHDLVDRPVPGSEGNFSTSSNLPVSSQGQQFSSVSQLPGPVPTSGGTDTQNTVNMSQADTEKLRQRQKLREIILQQQQQKKIASRQEKGPQDTAVVPHPVPLPHWQPESINQAFTRPPPPYPGSTRSPVIPPLGPRYAVFPKDQRGPYPPEVAGMGMRPHGFRFGFPGAGHGPMPSQDRFHVPQQIQGSGIPPHIRRPMSMEMPRPSNNPPLNNPVGLPQHFPPQGLPVQQHNILGQAFIELRHRAPDGRSRLPFAASPSSVIESPSHPRHGNFLPRPDFPGPRHTDPIRQPSQCLSNQLPVHPNLEQVPPSQQEQGHPAHQSSIVMRPLNHPLSGEFSEAPLSTSTPAETSPDNLEIAGQSSAGLEEKLDSDDPSVKELDVKDLEGVEVKDLDDEDLENLNLDTEDGKGDDLDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDLGDKKSMFNEELDLNVPIDDKLDNQCASVEPKTRDQGDKTMVLEDKDLPQRKSSVSSEIKTEALSPYSKEEIQSEIKNHDDSRGDADTACSQAASAQTNHSDRGKTALLTTDQDMLEKRCNQENAGPVVSAIQGSTPLPARDVMNSCDITGSTPVLSSLLSNEKCDDSDIRPSGSSPPSLPISPSTHGSSLPPTLIVPPSPLLDNTVNSNVTVVPRINHAFSQGVPVNPGFIQGQSSVNHNLGTGKPTNQTVPLTNQSSTMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNSLGMPPMVMSRFPFMGPSVAGTQNNDGQTLVPQAVAQDGSITHQISRPNPPNFGPGFVNDSQRKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQQQQCALAPPILMPGVQPQPPLVPGATSLTMSQPNFPMVPQQLQHQQHTAVISGHTSPARMPSLPGWQSNSASAHLPLNPPRIQPPIAQLSLKTCTPAPGTVSSANPQNGPPPRVEFDDNNPFSESFQERERKERLREQQERQRVQLMQEVDRQRALQQRMEMEQHCLMGAELANRTPVSQMPFYGSDRPCDFLQPPRPLQQSPQHQQQIGPVLQQQNVQQGSVNSPPNQTFMQTNEQRQVGPPSFVPDSPSASGGSPNFHSVKPGHGNLPGSSFQQSPLRPPFTPILPGTSPVANSNVPCGQDPAVTQGQNYSGSSQSLIQLYSDIIPEEKGKKKRTRKKKKDDDAESGKAPSTPHSDCAAPLTPGLSETTSTPAVSSPSELPQQRQQEPVEPVPVPTPNVSAGQPCIESENKLPNSEFIKETSNQQTHVNAEADKPSVETPNKTEEIKLEKAETQPSQEDTKVEEKTGNKIKDIVAGPVSSIQCPSHPVGTPTTKGDTGNELLKHLLKNKKASSLLTQKPEGTLSSDESSTKDGKLIEKQSPAEGLQTLGAQMQGGFGGGNSQLPKTDGASENKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSSDSFTHLKQQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVARALGPKPFQLPFRPQDDLLARAIAQGPKTVDVPASLPTPPHNNHEELRIQDHYGDRDTPDSFVPSSSPESVVGVEVNKYPDLSLVKEEPPEPVPSPIIPILPSISGKNSESRRNDIKTEPGTLFFTSPFGSSPNGPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSNAPDVPPMGLVSSHRVNPSLEYRQHLLLRGPPPGSANPPRLATSYRLKQPNVPFPPTSNGLSGYKDSSHGPAEGASLRPQWCCHCKVVILGSGVRKSCKDLTFVNKGSRENTKRMEKDIVFCSNNCFILYSSAAQAKNSDNKESLPSLPQSPMKEPSKAFHQYSNNISTLDVHCLPQFQEKVSPPASPPISFPPAFEAAKVESKPDELKVTVKLKPRLRTVPVGLEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTCLKPDPVPKDCRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCATKAQCMFFKDKTMLCPMHKPKGIHEQQLSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDSSPKDVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSNRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN
Tissue specificity：In adult, detected in testis, kidney, spleen and lung, weakly expressed in brain and absent in heart and liver. First detected throughout the embryo at 8 dpc when expression is strong in forebrain neuroepithelium and absent in heart. Expressed in the eye lens between 10 and 14.5 dpc. By 13 dpc, expressed strongly in spinal cord, hand/foot plates and gonads. {ECO:0000269|PubMed:16459028}.
Induction：
Developmental stage：
Protein families：Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily