SBNO2_MOUSE Q7TNB8
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UniProt:Q7TNB8
Recommended name：Protein strawberry notch homolog 2
EC number：
Alternative names：
Cleaved into：
GeneID：216161
Gene names (primary )：Sbno2
Gene names (synonym )：Sno Stno
Gene names (ORF )：
Length：1349
Mass：149294
Sequence：MLAVEPTMDGDFPPHELPPPGGGIQLQNRLLHCPWWGSFSPSLYPTFSSENQQFVGSTPFLGGQSCPETSYPTTATVPSFFSKSSDFPQDPSCLEDLSNASVFSSSVDSLSDIPDTPDFLQADSLNEVPTIWDVSTTSTTHDKLFIPSGPFSAPEDPVTSLSSTPLLISYQSHSQPEEEEGEEEEETEELGHAETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLALPTSDNSTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYGDNTTSEGVLFATYSALIGESQAGGQHRTRLRQILQWCGEGFDGVIVFDECHKAKNASSTKMGKAVLDLQSKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLSPAFQQVYNRAARLWAEALSVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVVIGLQSTGEARTREVLDENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGGKRKRRPRGRGPKASRLSLEAAGVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTHPTDDRGSLYPLQRDLQGPGVVERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPECVAEMTGRKGRVVSRPDGTVVFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGARALSRVLATIMGQTDNRVPLPQGYPGGDTAFFRDMKQGLLSVGIGSRESRSGCLDVEKDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEIDKKEGRYDMGILDLAPGINEIHEESQQVFLAPGHPQDGQVVFYKQISVDRGMKWEEALTRSLELKGPYDGFYLSYKVRGSKMSCLLAEQNRGEYFTVYKPNIGRQSQLETLDSLCRKFHRVTVEEAREPWESSYALSLEHCSHTTWNQRCRLTQEGKCCAQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDKKKQVGIKIPEGCVHRVLQELQLMDAEVKRRSTHGLAARPPTPRAITLPCGPGEVLDLTYSPPAEAFPTPPRFAFPSLPPPDPSSLMLGARDPATNPVELAHQSCDINFREVLEDMLRSLRAGPTETPAPLVGVGGGGTERQSVIHFSPPFPNS
Tissue specificity：Expressed in the spleen and bone marrow, and to a lesser extent in the kidney, liver, brain, skin, heart and muscle (PubMed:23980096). Expressed predominantly in osteoclasts, and to a lesser extent in T-cells, B-cells and osteoblasts (PubMed:23980096). Expressed in macrophages (PubMed:18025162). {ECO:0000269|PubMed:18025162, ECO:0000269|PubMed:23980096}.
Induction：Up-regulated by interleukin IL6 together with soluble interleukin receptor IL6R in astrocytes (PubMed:25903009). Up-regulated by interleukins such as IL1B or tumor necrosis factor TNF in astrocytes (at protein level) (PubMed:25903009). Up-regulated by interleukin IL6 together with soluble interleukin receptor IL6R in astrocytes (PubMed:25903009). Up-regulated also by other cytokines such as interleukin IL11, oncostatin M (OSM) and leukemia inhibitory factor (LIF) (PubMed:25903009). Up-regulated by interleukin such as IL1B or tumor necrosis factor TNF in astrocytes (PubMed:25903009). Up-regulated by lipopolysaccharide (LPS) (PubMed:25903009, PubMed:23980096). Up-regulated by interleukin IL10 in a STAT3-dependent manner in bone marrow derived macrophages (PubMed:18025162). Up-regulated by TNFSF11//RANKL in a c-Fos/FOS-dependent manner (PubMed:23980096). {ECO:0000269|PubMed:18025162, ECO:0000269|PubMed:23980096, ECO:0000269|PubMed:25903009}.
Developmental stage：
Protein families：SBNO family