DERL3_MOUSE Q9D8K3
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UniProt:Q9D8K3
Recommended name:Derlin-3
EC number:
Alternative names:(Degradation in endoplasmic reticulum protein 3) (Der1-like protein 3) (Protein IZP6)
Cleaved into:
GeneID:70377
Gene names (primary ):Derl3
Gene names (synonym ):Der3 Izp6
Gene names (ORF ):
Length:228
Mass:25978
Sequence:MAGQRLAAGFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLITTFLFFGPLGFGFFFNMLFVFRYCRMLEEGSFRGRKADFVFMFLFGGVLMTLLGFLGSLFFLGQALMAMLVYVWSRRSPHVRVNFFGLLNFQAPFLPWALMGFSLLLGNSVVTDLLGILVGHIYYFLEDVFPNQPGGKRLLLTPSVLKLLLDDPQEDPDYLPLPEEQPEL
Tissue specificity:Highly expressed in spleen, lung, liver, spleen and testis. Expressed at intermediate level in kidney. Weakly or not expressed in brain, heart and skeletal muscle. {ECO:0000269|PubMed:11422294}.
Induction:
Developmental stage:Expressed in neural cells during enbryogenesis. From 11.5 dpc until 14.5 dpc, it is mainly expressed in the forebrain. From 15.5 dpc until birth, expression in the forebrain becomes weaker but is still observed in the olfactory bulb and the skin around the eyes, nose, limbs and tail, showing that its pattern of expression changes from the central nervous system to the peripheral tissues during development. {ECO:0000269|PubMed:11422294}.
Protein families:Derlin family