CHIL3_MOUSE O35744
We list detailed information on various proteins on this webpage, which EnkiLife references when developing protein-related products. The protein data is sourced from UniProt, and since UniProt updates its information periodically, the data on our webpage may not always be up-to-date or may contain inaccuracies. If you notice any errors while browsing, we warmly welcome your feedback. Additionally, if you have any suggestions regarding any aspect of our website, please feel free to share them with us. As a token of our appreciation, we will offer a free product or a discount voucher for purchases to scientists who provide feedback. Please contact us at Email: order@enkilife.com; to share your feedback and get your rewards.
UniProt:O35744
Recommended name：Chitinase-like protein 3
EC number：EC 3.2.1.52
Alternative names：(Beta-N-acetylhexosaminidase Ym1) (Chitinase-3-like protein 3) (ECF-L) (Eosinophil chemotactic cytokine) (Secreted protein Ym1)
Cleaved into：
GeneID：12655
Gene names (primary )：Chil3
Gene names (synonym )：Chi3l3 Ym1
Gene names (ORF )：
Length：398
Mass：44458
Sequence：MAKLILVTGLAILLNVQLGSSYQLMCYYTSWAKDRPIEGSFKPGNIDPCLCTHLIYAFAGMQNNEITYTHEQDLRDYEALNGLKDKNTELKTLLAIGGWKFGPAPFSAMVSTPQNRQIFIQSVIRFLRQYNFDGLNLDWQYPGSRGSPPKDKHLFSVLVKEMRKAFEEESVEKDIPRLLLTSTGAGIIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKDGYTGENSPLYKSPYDIGKSADLNVDSIISYWKDHGAASEKLIVGFPAYGHTFILSDPSKTGIGAPTISTGPPGKYTDESGLLAYYEVCTFLNEGATEVWDAPQEVPYAYQGNEWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQRHFPLTSTLKGDLNIHSASCKGPY
Tissue specificity：Expressed in peritoneal cavity macrophages and in peritoneal and bone marrow-derived neutrophils. Abundantly expressed in bone marrow, with moderate levels detected in gastric antrum, spleen and in alveolar macrophages in lung. Not detected in brain, heart, liver, kidney, stomach, intestine, skeletal muscle, ovary, testis, thymus and lymph nodes (at protein level). Detected at low levels in bone marrow, spleen, thymus and lung. Barely detectable in intestine, kidney and coecum. {ECO:0000269|PubMed:10625674, ECO:0000269|PubMed:11297523, ECO:0000269|PubMed:11733538, ECO:0000269|PubMed:12101265, ECO:0000269|PubMed:15148607, ECO:0000269|PubMed:9828134}.
Induction：Up-regulated in response to IL3 and IL4, during the inflammatory response and upon parasitic infection. {ECO:0000269|PubMed:10625674, ECO:0000269|PubMed:11297523, ECO:0000269|PubMed:12101265, ECO:0000269|PubMed:12215441}.
Developmental stage：In yolk sac, first detected at low levels at 8.5 dpc, with significant expression detected at 10.5 dpc in myeloid precursor cells. In liver, expressed from 16.5 dpc to P7.5 with highest levels detected from 18.5 dpc to P0.5. In spleen, first detected at 16.5 dpc, with peak levels detected at 18.5 dpc and P0.5 and expression persisting through the spleen maturation to the adult stage. In bone marrow, high expression levels detected from 16.5 dpc until adulthood. In lung, first detected around the time of birth, with levels increasing significantly from P14.5 towards adulthood. {ECO:0000269|PubMed:12101265}.
Protein families：Glycosyl hydrolase 18 family, Chitinase class II subfamily