TERT_RAT Q673L6
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UniProt:Q673L6
Recommended name：Telomerase reverse transcriptase
EC number：EC:2.7.7.49
Alternative names：Telomerase catalytic subunit
Cleaved into：
GeneID：
Gene names (primary )：Tert
Gene names (synonym )：
Gene names (ORF )：
Length：1,125
Mass：126,934
Sequence：MPRAPRCPAVRSLLRSRYREVWPLATFVRRLGLEGSRLVQPGDPKVFRTLVAQCLVCVPWGSQPPPADLSFHQVSSLKELVSRVVQKLCERGERNVLAFGFALLNGARGGPPMAFTTSVHSYLPNSVTESLCVSGAWMLLLSRVGDDLLVYLLSHCALYLLVPPSCAYQVCGSPLYQICATTDTWSSVPAGYRPTRPVGGNFTNLGSAHQIKNSGHQEAPKPQALPSRGTKRLLSLTSTNVPSAKKARFEPALRVDKGPHRQVVPTPSGKTWAPSPAASPKVPPAAKNLSLKGKASDPSLSGSVCCKHKPSSSSLLSSPPQDAEKLRPFTETRHFLYSRGGGQEELNPSFLLNSLPPSLTGARRLVEIIFLGSRPRTSGPFCRTRRLPRRYWQMRPLFQQLLMNHAKCQYVRFLRSHCRFRTANQRVPDAMDTSPSHLTSLLRLHSSPWQVYGFLRACLRELVPAGLWGTRHNERRFLKNVKKFISLGKYAKLSLQELMWRVKVEDCHWLRSSPEKDTVPAAEHRLRERILAMFLFWLMDTYVVQLLRSFFYITETTFQKNRLFFYRKSVWSKLQSIGIRQQLERVQLRELSQEEVKHHQDTWLAMPICRLRFIPKLNGLRPIVNMSYGMDTRAFGKKKQTQCFTQSLKTLFSVLNYERTKHPNLMGASVLGTSDSYRIWRTFVLRVRALDQTPRMYFVKADVTGAYDAIPQDKLVEIVANIIRRSESMYCIRQYAVVQKDSQGQVHKSFRRQVSTLSDLQPYMGQFTKHLQDSDASALRNSVVIEQSISMNETGSSLLHFFLRFVRHSVVKIDGRFYVQCQGIPQGSSLSTLLCSLCFGDMENKLFAEVQQDGLLLRFVDDFLLVTPHLAHAKAFLSTLVHGVPEYGCMINLQKTVVNFPVETGALGGAAPHQLPAHCLFPWCGLLLDTRTLEVFCDYSGYGRTSIKMSLTFQGVSRAGKTMRYKLLSVLRLKCHGLFLDLQVNSLQTVCINIYKIFLLQAYRFHACVIRLPFGQHVRKNHAFFLGIISNLASCCYAILKVKNPGVSLRAKGAPGSFPPEATRWLCYQAFLLKLAAHSVTYKCLLGPLRTAQKQLCRKLPEATMTLLKTAADPALSTDFQTILD
Tissue specificity：Isoform 1 and isoform 2 expressed in thymus, liver, spleen, lung, kidney and testis. High level of inactive isoform 3 in adult hippocampus, low level in heart, cortex and cerebellum. 2 s
Induction：High activity in cortex at embryonic stage 16 and postnatal day 2. Low activity in cortex from postnatal day 5. 1 Publication
Developmental stage：Down-regulated by TGFbeta in fibroblasts. This inhibition is mediated by SMAD3. 1
Protein families：