SQSTM_HUMAN Q13501
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UniProt:Q13501
Recommended name：Sequestosome-1
EC number：
Alternative names：(EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Cleaved into：
GeneID：8878
Gene names (primary )：SQSTM1
Gene names (synonym )：ORCA OSIL
Gene names (ORF )：
Length：440
Mass：47687
Sequence：MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
Tissue specificity：Ubiquitously expressed. {ECO:0000269|PubMed:8650207}.
Induction：By proteasomal inhibitor PSI and prostaglandin J2 (PGJ2) (at protein level). By phorbol 12-myristate 13-acetate (PMA). Expression is directly activated by NFE2L2/NRF2; creating a positive feeback loop (PubMed:20452972). {ECO:0000269|PubMed:12700667, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:9762895}.
Developmental stage：
Protein families：