IL1AP_HUMAN Q9NPH3
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UniProt:Q9NPH3
Recommended name：Interleukin-1 receptor accessory protein
EC number：EC:3.2.2.6
Alternative names：(IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
Cleaved into：
GeneID：3556
Gene names (primary )：IL1RAP
Gene names (synonym )：C3orf13 IL1R3
Gene names (ORF )：
Length：570
Mass：65418
Sequence：MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV
Tissue specificity：Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:19481478, ECO:0000269|PubMed:20805474, ECO:0000269|PubMed:22723552, ECO:0000269|PubMed:23479569, ECO:0000269|PubMed:25595648}.
Induction：Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment. {ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:12781872}.
Developmental stage：
Protein families：Interleukin-1 receptor family