CML1_HUMAN Q99788
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UniProt:Q99788
Recommended name：Chemokine-like receptor 1
EC number：
Alternative names：(G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)
Cleaved into：
GeneID：1240
Gene names (primary )：CMKLR1
Gene names (synonym )：CHEMR23 DEZ
Gene names (ORF )：
Length：373
Mass：42322
Sequence：MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
Tissue specificity：Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269|PubMed:14530373, ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:8976386}.
Induction：Up-regulated by inflammatory cytokines TNF-alpha and IFN-gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells. {ECO:0000269|PubMed:14530373, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979}.
Developmental stage：Expressed during bone development.
Protein families：G-protein coupled receptor 1 family