CP7B1_MOUSE Q60991
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UniProt:Q60991
Recommended name：Cytochrome P450 7B1
EC number：EC 1.14.14.26
Alternative names：(24-hydroxycholesterol 7-alpha-hydroxylase) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (3-hydroxysteroid 7-alpha hydroxylase) (Hippocampal transcript 1 protein) (HCT-1) (Oxysterol 7-alpha-hydroxylase)
Cleaved into：
GeneID：13123
Gene names (primary )：Cyp7b1
Gene names (synonym )：
Gene names (ORF )：
Length：507
Mass：58470
Sequence：MQGATTLDAASPGPLALLGLLFAATLLLSALFLLTRRTRRPREPPLIKGWLPYLGMALKFFKDPLTFLKTLQRQHGDTFTVFLVGKYITFVLNPFQYQYVTKNPKQLSFQKFSSRLSAKAFSVKKLLTDDDLNEDVHRAYLLLQGKPLDALLETMIQEVKELFESQLLKITDWNTERIFAFCGSLVFEITFATLYGKILAGNKKQIISELRDDFFKFDDMFPYLVSDIPIQLLRNEESMQKKIIKCLTSEKVAQMQGQSKIVQERQDLLKRYYRHDDPEIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPGISVHFTREQLDSLVCLESTILEVLRLCSYSSIIREVQEDMNLSLESKSFSLRKGDFVALFPPLIHNDPEIFDAPKEFRFDRFIEDGKKKSTFFKGGKKLKTYVMPFGLGTSKCPGRYFAVNEMKLLLIMLLTYFDLEIIDRKPIGLNHSRMFLGIQHPDSAVSFRYKAKSWRS
Tissue specificity：Highly expressed in brain structures including the corpus callosum, the anterior commissure and fornix (PubMed:8530364). The hippocampal expression is particularly prominent in the dentate gyrus (PubMed:8530364). Expressed in liver and kidney. The hepatic expression is sexually dimorphic, predominantly detected in male liver while barely detectable in females (PubMed:8530364). Expressed in lymph nodes and spleens, in both lymphoid and stromal compartments (PubMed:22999953). Higher expression is detected in fibroblastic reticular cells, a type of stromal cells in the lymph nodes (PubMed:22999953). Also expressed at high levels in the outer follicle and at the B cell-T cell boundary of splenic germinal centers (PubMed:22999953). Expressed in dendritic cells (DCs) subpopulations being most abundant in CD8-positive DCs (PubMed:22999953). {ECO:0000269|PubMed:22999953, ECO:0000269|PubMed:8530364}.
Induction：
Developmental stage：
Protein families：Cytochrome P450 family