CNR1_MOUSE P47746
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UniProt:P47746
Recommended name：Cannabinoid receptor 1
EC number：
Alternative names：(CB-R) (CB1) (Brain-type cannabinoid receptor)
Cleaved into：
GeneID：12801
Gene names (primary )：Cnr1
Gene names (synonym )：
Gene names (ORF )：
Length：473
Mass：52831
Sequence：MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Tissue specificity：Expressed in brain neurons (at protein level) (PubMed:22388959). Detected throughout the striatum, cortex and hippocampus, with highest levels in the lateral striatum (PubMed:15606779, PubMed:10891614, PubMed:22388959). In rostral brain regions, high expression levels in the dorsal lateral striatum, while in the caudal brain regions, high levels are observed in the ventral lateral striatum (PubMed:10891614). Expressed in neurons (PubMed:10891614). In the hypothalamus, expressed in both GABAergic and glutamatergic presynaptic terminals of POMC neurons (at protein level) (PubMed:25869131, PubMed:25707796). Expressed in striated muscles, including skeletal muscles (gastrocnemius and rectus abdominis) and myocardium (at protein level) (PubMed:26671069, PubMed:27826249). Expressed in the liver, with highest levels in Kupffer cells and lower levels in endothelial cells as well as hepatocytes, particularly in perivascular areas (at protein level) (PubMed:15864349, PubMed:21987372). The hepatic expression level is up-regulated in obese mice compared to lean animals (PubMed:21987372). {ECO:0000269|PubMed:10891614, ECO:0000269|PubMed:15606779, ECO:0000269|PubMed:15864349, ECO:0000269|PubMed:21987372, ECO:0000269|PubMed:22388959, ECO:0000269|PubMed:25707796, ECO:0000269|PubMed:25869131, ECO:0000269|PubMed:26671069, ECO:0000269|PubMed:27826249}.
Induction：Up-regulated by endocannabinoid anandamide/AEA (PubMed:21987372, PubMed:23955712). Down-regulated by IL1B (PubMed:23955712). Up-regulated in the liver of animals on a high-fat diet compared to regular diet (PubMed:15864349, PubMed:21987372). {ECO:0000269|PubMed:15864349, ECO:0000269|PubMed:21987372, ECO:0000269|PubMed:23955712}.
Developmental stage：
Protein families：G-protein coupled receptor 1 family