SLAI1_MOUSE Q68FF7
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UniProt:Q68FF7
Recommended name：SLAIN motif-containing protein 1
EC number：
Alternative names：
Cleaved into：
GeneID：105439
Gene names (primary )：Slain1
Gene names (synonym )：
Gene names (ORF )：
Length：579
Mass：61307
Sequence：MMAEQVKCASPVAASGAGPGPVVNAELEVKKLQELVRKLEKQNEQLRSRAASAAAAPHLLLLQPPPPSAPPPAGACSPLATHRAPASTTSPGPGALGPAFPGTYCLPSPAPSLLCSLQPADAPFVYSKPAAGFFGGGGSPEPGTAGTPPGEAATPPLPPPTLLDEVEPLDLESLAAWSEEDDYTWLYVGSSKTFTSPEKSPSPLQWCRHVLDNPTPEMEAARRSLRFRLEQGYTSRGSPLSPQSSIDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASVSRNSSSVSLSSGKKGTCSDQEYDRYSLEDEEEFDHLPPPQPRLPRCSPFQRGIPHSQTFSSIRDCRRSPSTQYFPSNNFQQPQYYPPQAQTADQQPNRTNGDKLRRSMPNLARMPSTAAASSNLSSPVTVRSSQSFDSSLHGAGSGVSRVPSCIPSPGQIQHRVHSVGHFPVPIRQPLKATAYVSPTVQGSSSSGSSGSSGGSGSGMPLSNGTQLYSTTGIPTPNKAAASGILGRSALPRPSLAINGSNLPRSKIAQPVRSFLQPPKPLSSLSTLRDGNWRDGCY
Tissue specificity：Expressed in embryonic stem cells (PubMed:16546155). Expressed in adult bone marrow, brain, kidney, lung, testis and thymus (PubMed:16546155, PubMed:20563991). Expressed in colon (PubMed:20563991). Isoform 1 is highly expressed in brain (PubMed:20563991). Isoform 2 is more widely expressed in bone marrow, brain, colon, kidney, lung and thymus (PubMed:20563991). {ECO:0000269|PubMed:16546155, ECO:0000269|PubMed:20563991}.
Induction：
Developmental stage：During embryonic stem cell differentiation, expression peaks at d2 and d3 (epiblast stage) (PubMed:16546155). In postimplantation embryos widely expressed throughout 6.5-7.0 dpc, followed by higher levels of expression in the headfold neurectoderm at 7.5 dpc (PubMed:16546155). At 8.5 dpc, observed in the neural tube and optic vesicles (PubMed:16546155). At 9.0-9.5 dpc, expressed at sites of imminent neural tube closure in the midbrain, hindbrain, and tailbud and in the dorsal aspects of the somites (PubMed:16546155). At 9.5 dpc, expressed within the neuroepithelium surrounding the telencephalic, mesencephalic and optic vesicles and in neural crest cells on either side of the mesencephalic vesicles, along the neural tube continuous with the tailbud, in the neural crest-derived dorsal root ganglia, in the surface ectoderm of the branchial arches as well as the primitive gut tube (PubMed:20563991). At 11.5 dpc, predominantly expressed within the forebrain, eye and neural tube, and weaker expression within the optic and oropharyngeal regions, in the epithelium of the olfactory pit, optic stalk and otic vesicle, parts of the gut tube, particularly within the lumen of the midgut loop and the stomach, in branchial arches and in the condensing mesenchyme of the developing limb buds (PubMed:20563991). At 11.5 dpc, also expressed within the neuroepithelium surrounding both the fourth and telencephalic ventricles (PubMed:20563991). At 13.5 dpc, expressed throughout the developing nervous system with most prominent expression in forebrain, midbrain and spinal cord, including the dorsal root ganglia and the olfactory bulb and within the endoderm derived midgut loop in the physiological umbilical hernia, as well as in the eye and in the main bronchi of the lung and within the developing metanephric tubules (PubMed:20563991). At 13.5 dpc, also expressed at the superficial layers of the neuroepithelium and the ependymal layers surrounding the fourth and lateral ventricles and in neurons of the dorsal root ganglia and in dorsal roots between the cartilage primordia as well as in cranial sensory ganglia (PubMed:20563991). Also expressed along the apical epidermal ridge and in the forelimb and hind limb (PubMed:20563991). {ECO:0000269|PubMed:16546155, ECO:0000269|PubMed:20563991}.
Protein families：SLAIN motif-containing family