ZIC1_MOUSE P46684
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UniProt:P46684
Recommended name：Zinc finger protein ZIC 1
EC number：
Alternative names：(Zinc finger protein of the cerebellum 1)
Cleaved into：
GeneID：22771
Gene names (primary )：Zic1
Gene names (synonym )：Zic
Gene names (ORF )：
Length：447
Mass：48331
Sequence：MLLDAGPQYPAIGVTTFGASRHHSAGDVAERDVGLGINPFADGMGAFKLNPSSHELASAGQTAFTSQAPGYAAAAALGHHHHPGHVGSYSSAAFNSTRDFLFRNRGFGDAAAAASAQHSLFAASAGGFGGPHGHTDAAGHLLFSGLHEQAAGHASPNVVNGQMRLGFSGDMYPRPEQYGQVTSPRSEHYAAPQLHGYGPMNVNMAAHHGAGAFFRYMRQPIKQELICKWIEPEQLANPKKSCNKTFSTMHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSSQGSQPSPAASSGYESSTPPTIVSPTTDNPTTSSMSPSSSAVHHTAGHSALSSNFNEWYV
Tissue specificity：Expressed in osteoblasts (at protein level). Expressed in the CNS. A high level expression is seen in the cerebellum, while a low level expression is seen in the olfactory bulb, diencephalon, and brainstem. Expressed in lumbar spine and iliac crest. {ECO:0000269|PubMed:19303920, ECO:0000269|PubMed:20354137, ECO:0000269|PubMed:7931345}.
Induction：
Developmental stage：Expressed in progenitor cells in the dorsal third of the ventricular zone at 12.5 dpc. Expressed in newly emerging pontine gray nucleus (PGN) precursor cells of the extramural migratory stream (ems) between 12.5 and 14.5 dpc. Expressed in precerebellar mossy fiber (MF) neurons of the PGN (located either rostromedially or caudolaterally) persisted through at least P8 after birth (at protein level). In the early embryonic stage, it is expressed in the dorsal half of the neural tube and adjacent mesenchyme, and in the developing cerebellum it is expressed persistently in the granule cell lineage throughout the prenatal and postnatal periods. {ECO:0000269|PubMed:11944941, ECO:0000269|PubMed:7931345}.
Protein families：GLI C2H2-type zinc-finger protein family