RTN4_MOUSE Q99P72
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UniProt:Q99P72
Recommended name：Reticulon-4
EC number：
Alternative names：(Neurite outgrowth inhibitor) (Nogo protein)
Cleaved into：
GeneID：68585
Gene names (primary )：Rtn4
Gene names (synonym )：Kiaa0886 Nogo
Gene names (ORF )：
Length：1162
Mass：126613
Sequence：MEDIDQSSLVSSSADSPPRPPPAFKYQFVTEPEDEEDEEDEEEEEDDEDLEELEVLERKPAAGLSAAPVPPAAAPLLDFSSDSVPPAPRGPLPAAPPTAPERQPSWERSPAASAPSLPPAAAVLPSKLPEDDEPPARPPAPAGASPLAEPAAPPSTPAAPKRRGSGSVDETLFALPAASEPVIPSSAEKIMDLKEQPGNTVSSGQEDFPSVLFETAASLPSLSPLSTVSFKEHGYLGNLSAVASTEGTIEETLNEASRELPERATNPFVNRESAEFSVLEYSEMGSSFNGSPKGESAMLVENTKEEVIVRSKDKEDLVCSAALHNPQESPATLTKVVKEDGVMSPEKTMDIFNEMKMSVVAPVREEYADFKPFEQAWEVKDTYEGSRDVLAARANMESKVDKKCFEDSLEQKGHGKDSESRNENASFPRTPELVKDGSRAYITCDSFSSATESTAANIFPVLEDHTSENKTDEKKIEERKAQIITEKTSPKTSNPFLVAIHDSEADYVTTDNLSKVTEAVVATMPEGLTPDLVQEACESELNEATGTKIAYETKVDLVQTSEAIQESIYPTAQLCPSFEEAEATPSPVLPDIVMEAPLNSLLPSTGASVAQPSASPLEVPSPVSYDGIKLEPENPPPYEEAMSVALKTSDSKEEIKEPESFNAAAQEAEAPYISIACDLIKETKLSTEPSPEFSNYSEIAKFEKSVPDHCELVDDSSPESEPVDLFSDDSIPEVPQTQEEAVMLMKESLTEVSETVTQHKHKERLSASPQEVGKPYLESFQPNLHITKDAASNEIPTLTKKETISLQMEEFNTAIYSNDDLLSSKEDKMKESETFSDSSPIEIIDEFPTFVSAKDDSPKEYTDLEVSNKSEIANVQSGANSLPCSELPCDLSFKNTYPKDEAHVSDEFSKSRSSVSKVPLLLPNVSALESQIEMGNIVKPKVLTKEAEEKLPSDTEKEDRSLTAVLSAELNKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNSTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQAQIDHYLGLANKSVKDAMAKIQAKIPGLKRKAE
Tissue specificity：Isoform A: highly expressed in brain but not deteceted in aorta, femoral and carotid arteries (PubMed:15034570). Isoform A: main isoform in neurons but isoforms B and C are also expressed. Isoform D is expressed at very low levels (PubMed:27786289, PubMed:23625008). Isoform B is highly expressed in endothelial cells and vascular smooth muscle cells, including blood vessels and mesenteric arteries (PubMed:26301690, PubMed:15034570). Isoform B: expressed in bronchial and alveolar epithelial cells as well as vascular endothelial cells of lungs (PubMed:26174362). Isoform B: expressed in splenocytes, T-cells, B-cells, bone marrow derived dendritic cells and macrophages (at protein level) (PubMed:25917084, PubMed:19805174). Isoform B2: expressed in B-cells, bone marrow dendritic cells and macrophages (at protein level) (PubMed:25917084). Isoform C: expressed in cardiomyocytes (PubMed:27763637). {ECO:0000269|PubMed:15034570, ECO:0000269|PubMed:19805174, ECO:0000269|PubMed:23625008, ECO:0000269|PubMed:25917084, ECO:0000269|PubMed:26174362, ECO:0000269|PubMed:26301690, ECO:0000269|PubMed:27763637, ECO:0000269|PubMed:27786289}.
Induction：Isoform C: expression is induced by hypoxic treatments or myocardial infarction (PubMed:27763637). Isoform C: is negatively regulated by the microRNA miR-182 (PubMed:27763637). Isoform B: expression is down-regulated by LPS in alveolar epithelium (PubMed:26174362). Isoform B: induced during tissue ischemia (PubMed:19805174). Isoform B2: induced during tissue ischemia (PubMed:19805174). {ECO:0000269|PubMed:19805174, ECO:0000269|PubMed:26174362, ECO:0000269|PubMed:27763637}.
Developmental stage：Expressed in radial glial cells, migrating postmitotic as well as postmigratory neurons of the embryonic cortex (PubMed:20093372). Expression is down-regulated in the ganglion cell layer and in the plexiform layer of the retina at P8 (PubMed:20093372). Isoform B: expression increases in regenirating liver (PubMed:23299899). {ECO:0000269|PubMed:20093372, ECO:0000269|PubMed:23299899}.
Protein families：