CADM1_MOUSE Q8R5M8
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UniProt:Q8R5M8
Recommended name：Cell adhesion molecule 1
EC number：
Alternative names：(Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Cleaved into：
GeneID：54725
Gene names (primary )：Cadm1
Gene names (synonym )：Igsf4 Necl2 Ra175 Syncam SynCam1 Tslc1
Gene names (ORF )：
Length：456
Mass：49788
Sequence：MASAVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAFELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDTTATTEPAVHDSRAGEEGTIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
Tissue specificity：Expressed dominantly in epithelial cells but not expressed in fibroblast cells (at protein level) (PubMed:12826663). Expressed in the T-cell area of lymph nodes, specifically in CD8+ and CD4- CD8- dendritic cells (at protein level) (PubMed:19752223). Expressed in CD8+ dendritic cells in the spleen (at protein level) (PubMed:19752223). Expressed in CD103+ dendritic cells in the small intestine lamina propria and mesenteric lymph nodes (at protein level) (PubMed:24687959). Expressed in brain, lung, kidney, testis, heart, spleen and liver, but not expressed in skeletal muscle (PubMed:12242005, PubMed:12606335, PubMed:12202822). {ECO:0000269|PubMed:12202822, ECO:0000269|PubMed:12242005, ECO:0000269|PubMed:12606335, ECO:0000269|PubMed:12826663, ECO:0000269|PubMed:19752223, ECO:0000269|PubMed:24687959}.
Induction：
Developmental stage：Expressed in spermatogenic cells during early spermatogenesis. Expression increases in intermediate spermatogonia through to zygotene spermatocytes but becomes diminished in the steps from early pachytene spermatocytes through to round spermatids. After meiosis, expression reappears in spermatids and is present in elongating spermatids until spermiation. Not detected in Sertoli cells. {ECO:0000269|PubMed:12606335}.
Protein families：Nectin family