SPTC1_MOUSE O35704
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UniProt:O35704
Recommended name：Serine palmitoyltransferase 1
EC number：EC 2.3.1.50
Alternative names：(Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)
Cleaved into：
GeneID：268656
Gene names (primary )：Sptlc1
Gene names (synonym )：Lcb1
Gene names (ORF )：
Length：473
Mass：52535
Sequence：MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLVFSKTYKLQERSDLTAKEKEELIEEWQPEPLVPPVSKNHPALNYNIVSGPPTHNIVVNGKECVNFASFNFLGLLANPRVKATAFSSLKKYGVGTCGPRGFYGTFDVHLDLEERLAKFMKTEEAIIYSYGFSTIASAIPAYSKRGDIIFVDSAACFAIQKGLQASRSDIKLFKHNDVADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESLSPALHLQLEESTGSREKDVKLLQAIVDQCMDKGIALTQARYLDKEEKCLPPPSIRVVVTVEQTEEELQRAASTIREAAQAVLL
Tissue specificity：Expressed in a variety of tissues. Highest expression in brain, kidney and liver (PubMed:21994399). Expressed in brown and white adipose tissues (PubMed:27818258). {ECO:0000269|PubMed:21994399, ECO:0000269|PubMed:27818258}.
Induction：Expression levels at protein level increase upon high-fat diet. mRNA levels remain unchanged. {ECO:0000269|PubMed:21994399}.
Developmental stage：Highly expressed after birth, expression decreases 2 weeks after birth and is maintained until, at least, 18 months. {ECO:0000269|PubMed:21994399}.
Protein families：Class-II pyridoxal-phosphate-dependent aminotransferase family