Phospho-4E BP1 (Thr46) Rabbit Monoclonal Antibody-Phospho Antibody-EnkiLife-Recombinant Proteins,Antibodies,Kits,Cell Biology

Phospho-4E BP1 (Thr46) Rabbit Monoclonal Antibody

Summary

Production Name	Phospho-4E BP1 (Thr46) Rabbit Monoclonal Antibody
Description	Recombinant Rabbit Monoclonal antibody
Host	Rabbit
Application	WB,IHC
Reactivity	Human,Mouse,Rat

Performance

Conjugation	Unconjugated
Modification	Phosphorylated
Isotype	IgG
Clonality	Monoclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification	Affinity Purified

Immunogen

Gene Name	EIF4EBP1
Alternative Names	EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Gene ID	1978
SwissProt ID	Q13541

Application

Dilution Ratio	WB: 1/500-1/1000 IHC: 1/50-1/100
Molecular Weight	Calculated MW: 13 kDa; Observed MW: 15-20 kDa

Background

Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

Research Area

Epigenetics and Nuclear Signaling