Phospho-4E BP1 (Thr70) Rabbit Polyclonal Antibody-Phospho Antibody-EnkiLife-Recombinant Proteins,Antibodies,Kits,Cell Biology

Phospho-4E BP1 (Thr70) Rabbit Polyclonal Antibody

Summary

Production Name	Phospho-4E BP1 (Thr70) Rabbit Polyclonal Antibody
Description	Primary antibody
Host	Rabbit
Application	IHC
Reactivity	Human

Performance

Conjugation	Unconjugated
Modification	Phosphorylated
Isotype	IgG
Clonality	Polyclonal Antibody
Form	Liquid
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification	Affinity Purified

Immunogen

Gene Name	EIF4EBP1
Alternative Names	EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Gene ID	1978
SwissProt ID	Q13541

Application

Dilution Ratio	IHC: 1/50-1/100
Molecular Weight	-

Background

Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity.

Research Area

Epigenetics and Nuclear Signaling