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CSF Family

The colony-stimulating factor (CSF) family comprises soluble glycoproteins that govern the survival, proliferation and lineage-specific differentiation of hematopoietic progenitors while activating mature blood cells. Four major members are recognized: granulocyte-macrophage CSF (GM-CSF), macrophage CSF (M-CSF/CSF-1), granulocyte CSF (G-CSF) and multipotential CSF (IL-3). GM-CSF, G-CSF and M-CSF engage distinct α-chains coupled to either the common β-subunit (GM-CSFRβ) or LIFRβ, triggering JAK2-STAT5/3, PI3K-AKT and ERK cascades that promote myeloid commitment toward granulocytes, monocytes/macrophages or dendritic cells. Beyond hematopoiesis, CSFs contribute to embryo implantation, placental development, tissue repair and tumor microenvironment remodeling. Recombinant G-CSF (filgrastim) and GM-CSF (sargramostim) are standard of care for chemotherapy-induced neutropenia, stem-cell mobilization and immune augmentation, and are stockpiled for acute radiation syndrome, leukemia and adjuvant immunotherapy.

Product List

Validation Data

GMP Recombinant Human GM-CSF (Catalog: PCH90015)

                     GM-CSF SDS-PAGE image

                      Bioactivity image: The ED50 for this effect is ≤0.2 ng/mL.

GMP Recombinant Human G-CSF (Catalog: PCH90053)

                        G-CSF SDS-PAGE image

Bioactivity image: The ED50 for this effect is ＜0.5 ng/ml, corresponding to a specific activity of ≥ 1×107 units/mg.

References

1. Biology and action of colony--stimulating factor-1. Stanley ER, et al. Mol Reprod Dev.1997. [PMID: 8981357]

2. Recent advances of colony-stimulating factor-1 receptor (CSF-1R) kinase and its inhibitors. El-Gamal MI, et al. J Med Chem. 2018. [PMID: 29293000]

3. Colony-stimulating factor 1 receptor signaling in the central nervous system and the potential of its pharmacological inhibitors to halt the progression of neurological disorders. Tarale P, et al. Inflammopharmacology. 2022. [PMID: 35290551]