CLCKA_RAT Q06393
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UniProt:Q06393
Recommended name:Chloride channel protein ClC-Ka
EC number:
Alternative names:ClC-K1 1 Publication
Cleaved into:
GeneID:79425
Gene names (primary ):Clcnka
Gene names (synonym ):Clcnk1
Gene names (ORF ):
Length:
Mass:
Sequence:
Tissue specificity:Expressed predominantly in the kidney. Expressed strongly in the cortical thick ascending limb and the distal convoluted tubule, with minor expression in the S3 segment of the proximal tubule and the cortical collecting tubule. 1
Induction:
Developmental stage:Regulated in parallel with BSND under furosemide treatment. Decreased to half in the inner medulla under furosemide treatment. In the renal cortex and outer medulla levels were weak and did not change. Regulation with BSND in inner medulla is limited to the thin limb; levels in collecting ducts were not affected by furosemide treatment. During furosemide treatment selective down-regulation with BSND in thin limb plays a role in maintaining salt and water homeostasis. 1
Protein families: