FGF Family
The Fibroblast Growth Factor (FGF) family comprises a group of structurally related signaling proteins that play crucial roles in embryonic development, cell proliferation, differentiation, migration, angiogenesis, tissue repair, and metabolic regulation. In humans, the FGF family includes 18 canonical members (FGF1–FGF10 and FGF16–FGF23), which are classified into six subfamilies based on sequence homology and functional characteristics. While most FGFs act locally in a paracrine manner, the FGF19 subfamily (FGF19, FGF21, and FGF23) functions endocrinely, regulating systemic metabolism of bile acids, glucose, and phosphate. FGFs exert their effects by binding to FGF receptors (FGFRs), activating downstream signaling pathways such as MAPK and PI3K/AKT, thereby influencing various cellular processes.
Product List
| Target | Catalog# | Product Name | Reactivity | Predicted MW |
|---|---|---|---|---|
| FGF-2/bFGF | PEH90008 | GMP Recombinant Human bFGF/FGF-2 | Human | 17 kDa |
| FGF-4 | PCH90011 | GMP Recombinant Human FGF-7/KGF | Human | 18.8 kDa |
| FGF-7/KGF | PCH90010 | GMP Recombinant Human FGF-4 | Human | 19.3 kDa |
| FGF-9 | PCH90012 | GMP Recombinant Human FGF-9 | Human | 23.2 kDa |
| FGF-10/KGF2 | PCH90007 | GMP Recombinant Human FGF-10/KGF2 | Human | 19.3 kDa |
| bFGF/FGF-2 | PEB90049 | GMP Recombinant Bovine bFGF/FGF-2 | Bovine | 16.5 kDa |
| bFGF/FGF-2 | PEF90050 | GMP Recombinant Fish bFGF/FGF-2 | Fish | 17.1 kDa |
Validation Data
GMP Recombinant Human bFGF/FGF-2 (Catalog: PEH90008)
bFGF/FGF-2 SDS-PAGE image
Bioactivity image: The ED50 this effect is≤2.0 ng/mL.GMP Recombinant Human FGF-7/KGF (Catalog: PCH90011)
FGF-7/KGF SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤10 ng/mL.GMP Recombinant Human FGF-4 (Catalog: PCH90010)
FGF-4 SDS-PAGE image
Bioactivity image: The ED50 for this effect is 0.25-1 ng/mL.GMP Recombinant Human FGF-9 (Catalog: PCH90012)
FGF-9 SDS-PAGE image
Bioactivity image: The ED50 for this effect is 1-3 ng/mL.GMP Recombinant Human FGF-10/KGF2 (Catalog: PCH90007)
FGF-10/KGF2 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤10 ng/mL.GMP Recombinant Bovine bFGF/FGF-2 (Catalog: PEB90049) GMP Recombinant Fish bFGF/FGF-2 (Catalog: PEF90050 )
bFGF/FGF-2 SDS-PAGE image
Bioactivity image: The ED50 for this effect is ≤2.0 ng/mL.References
1. Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance. Edirisinghe O, et al. Biomolecules. 2024. [PMID: 39766329]
2. FGF/FGFR signaling in health and disease. Xie Y, et al. Signal Transduct Target Ther. 2020. [PMID: 32879300]
3. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Wiedemann M, et al. Genomics. 2000. [PMID: 11031111]
4. Exploring mechanisms of FGF signalling through the lens of structural biology. Goetz R, et al. Nat Rev Mol Cell Biol. 2013. [PMID: 23403721]
5. Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting. Farrell B, et al. Biochem Soc Trans. 2018. [PMID: 30545934]